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Biomechanical Parameters of Gait in Patients With Parkinson's Disease and Parkinsonian Syndromes

This study has been terminated.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00139321
First Posted: August 31, 2005
Last Update Posted: January 8, 2013
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Institut National de la Santé Et de la Recherche Médicale, France
Information provided by (Responsible Party):
Marie-laure Welter, Groupe Hospitalier Pitie-Salpetriere
  Purpose
Gait disorders and falls are frequent in patients with parkinsonian syndromes. In patients with Parkinson's disease (PD), these signs occurred later during the course of the disease in comparison to patients with other degenerative parkinsonian disorders. The pathophysiology of these symptoms are still not fully understood. Gait initiation challenges the balance control system as the body moves from an upright stable static posture to a continuously unstable gait. The aim of this study is to analyse the gait initiation process in patients with parkinsonian disorders.

Condition Intervention
Gait Disorders, Neurologic Device: Force platform and electromyography

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Biomechanical Parameters of Gait in Patients With Parkinson's Disease and Parkinsonian Syndromes

Resource links provided by NLM:


Further study details as provided by Marie-laure Welter, Groupe Hospitalier Pitie-Salpetriere:

Primary Outcome Measures:
  • Biomechanical gait initiation parameters

Estimated Enrollment: 110
Study Start Date: June 2004
Study Completion Date: July 2007
Primary Completion Date: July 2007 (Final data collection date for primary outcome measure)
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Patients able to walk without assistance
  • Patients with Parkinson's disease or other degenerative parkinsonian syndromes (progressive supranuclear palsy [PSP], multiple system atrophy [MSA], corticobasal degeneration [CBD], etc.)

Exclusion Criteria:

  • Other parkinsonian syndromes
  • Dementia
  • Neuroleptic treatment
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00139321


Locations
France
Centre d'Investigation Clinique-Hôpital Pitié-Salpetriere
Paris, France, 75013
Sponsors and Collaborators
Groupe Hospitalier Pitie-Salpetriere
Institut National de la Santé Et de la Recherche Médicale, France
Investigators
Study Director: Yves Agid, MD, PhD CIC-Pitié-Salpêtrière
  More Information

Responsible Party: Marie-laure Welter, MD, PhD, Groupe Hospitalier Pitie-Salpetriere
ClinicalTrials.gov Identifier: NCT00139321     History of Changes
Other Study ID Numbers: RBM0260
First Submitted: August 30, 2005
First Posted: August 31, 2005
Last Update Posted: January 8, 2013
Last Verified: January 2013

Keywords provided by Marie-laure Welter, Groupe Hospitalier Pitie-Salpetriere:
Gait disorders
Postural instability
parkinsonian syndrome
Gait initiation
Parkinson's disease
Adults

Additional relevant MeSH terms:
Parkinson Disease
Nervous System Diseases
Gait Disorders, Neurologic
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases
Neurologic Manifestations
Signs and Symptoms