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ClinicalTrials.gov Identifier: NCT00137319
Recruitment Status :
(Aims of the study re-evaluated, did not justify allocation of resources.)
This study will see if a special piece of equipment can help burn patients who have been in bed for a long time to get out of bed without feeling dizzy or faint.
Condition or disease
Device: Impedance threshold device
To measure stroke volume, cardiac output, arterial blood pressure and cerebral blood flow velocity in human patients while they undergo exposure to head-up tilt that is designed to test their tolerance to an orthostatic challenge.
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Ages Eligible for Study:
18 Years to 65 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Military or civilian males or females between the ages of 18-65 years
Burn injury with at least one unburned finger for Portapres measurement
Minimum of 96 hours bedrest or physician directive to tilt
Age < 18 and > 65 years
Facial burns when application of ITD device would cause further trauma
Medical monitoring devices that preclude the use of the ITD
Signs of cardiac abnormalities, autonomic dysfunction
Chronic obstructive pulmonary disease (COPD), or any other respiratory limitations (ventilator dependent, intubated, tracheostomy) limiting use of ITD
History of pre-syncopal/syncopal episodes or orthostatic hypotension
History of atherosclerotic coronary heart disease
Patients taking any kind of cardiovascular pressor medications
Inability to obtain a Portapres pulse wave validated by blood pressure cuff with +/- 5mmHg diastolic blood pressure