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Tonsillectomy in Recurrent Tonsillitis

This study is ongoing, but not recruiting participants.
Information provided by:
Oulu University Hospital Identifier:
First received: August 26, 2005
Last updated: December 27, 2006
Last verified: December 2006
The purpose of this study is to determine whether tonsillectomy is effective in preventing further streptococcal pharyngitis episodes in patients with recurrent tonsillitis.

Condition Intervention
Procedure: (adeno)tonsillectomy

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Effect of Tonsillectomy on Preventing Recurrent Streptococcal Throat Infections: A Randomized Controlled Trial

Resource links provided by NLM:

Further study details as provided by Oulu University Hospital:

Primary Outcome Measures:
  • microbiologically confirmed streptococcal pharyngitis episodes

Secondary Outcome Measures:
  • side effects
  • symptoms
  • quality of life issues

Estimated Enrollment: 70
Study Start Date: October 2001
Estimated Study Completion Date: December 2005
Detailed Description:

Tonsillectomy is widely used worldwide in recurrent streptococcal tonsillitis, but its effect remains unknown.

In this randomized controlled trial, the effect of tonsillectomy (compared to watchful waiting) in preventing further culture proven symptomatic streptococcal pharyngitis episodes is studied. In addition, symptoms after the operation, side effects, and life quality issues are recorded.


Ages Eligible for Study:   14 Years and older   (Child, Adult, Senior)
Genders Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • At least 3 tonsillitis episodes during the preceding year (at least one verified by culture or antigen testing)

Exclusion Criteria:

  • Other serious illness
  • Long term antibiotic treatment for other disease
  • Documented immunologic disorder
  • Pregnancy
  Contacts and Locations
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Please refer to this study by its identifier: NCT00136877

Oulu University Hospital
Oulu, Finland, FIN-90029
Sponsors and Collaborators
Oulu University Hospital
Study Director: Olli-Pekka Alho, MD Dept of Otolaryngology, University of Oulu, Finland
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00136877     History of Changes
Other Study ID Numbers: Diary nro 135/2001 
Study First Received: August 26, 2005
Last Updated: December 27, 2006
Health Authority: Finland: Finnish Medicines Agency

Keywords provided by Oulu University Hospital:
recurrent tonsillitis

Additional relevant MeSH terms:
Pharyngeal Diseases
Stomatognathic Diseases
Respiratory Tract Infections
Respiratory Tract Diseases
Otorhinolaryngologic Diseases processed this record on January 17, 2017