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Tonsillectomy in Recurrent Tonsillitis

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00136877
Recruitment Status : Unknown
Verified December 2006 by Oulu University Hospital.
Recruitment status was:  Active, not recruiting
First Posted : August 29, 2005
Last Update Posted : December 29, 2006
Information provided by:
Oulu University Hospital

Brief Summary:
The purpose of this study is to determine whether tonsillectomy is effective in preventing further streptococcal pharyngitis episodes in patients with recurrent tonsillitis.

Condition or disease Intervention/treatment Phase
Tonsillitis Procedure: (adeno)tonsillectomy Not Applicable

Detailed Description:

Tonsillectomy is widely used worldwide in recurrent streptococcal tonsillitis, but its effect remains unknown.

In this randomized controlled trial, the effect of tonsillectomy (compared to watchful waiting) in preventing further culture proven symptomatic streptococcal pharyngitis episodes is studied. In addition, symptoms after the operation, side effects, and life quality issues are recorded.

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Study Type : Interventional  (Clinical Trial)
Enrollment : 70 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Effect of Tonsillectomy on Preventing Recurrent Streptococcal Throat Infections: A Randomized Controlled Trial
Study Start Date : October 2001
Study Completion Date : December 2005

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. microbiologically confirmed streptococcal pharyngitis episodes

Secondary Outcome Measures :
  1. side effects
  2. symptoms
  3. quality of life issues

Information from the National Library of Medicine

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Ages Eligible for Study:   14 Years and older   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • At least 3 tonsillitis episodes during the preceding year (at least one verified by culture or antigen testing)

Exclusion Criteria:

  • Other serious illness
  • Long term antibiotic treatment for other disease
  • Documented immunologic disorder
  • Pregnancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00136877

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Oulu University Hospital
Oulu, Finland, FIN-90029
Sponsors and Collaborators
Oulu University Hospital
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Study Director: Olli-Pekka Alho, MD Dept of Otolaryngology, University of Oulu, Finland
Publications automatically indexed to this study by Identifier (NCT Number):
Layout table for additonal information Identifier: NCT00136877    
Other Study ID Numbers: Diary nro 135/2001
First Posted: August 29, 2005    Key Record Dates
Last Update Posted: December 29, 2006
Last Verified: December 2006
Keywords provided by Oulu University Hospital:
recurrent tonsillitis
Additional relevant MeSH terms:
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Pharyngeal Diseases
Stomatognathic Diseases
Respiratory Tract Infections
Respiratory Tract Diseases
Otorhinolaryngologic Diseases