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Transcranial Magnetic Stimulation for Post-Traumatic Stress Disorder

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified March 2005 by White River Junction VAMC.
Recruitment status was:  Recruiting
Information provided by:
White River Junction VAMC Identifier:
First received: August 23, 2005
Last updated: October 28, 2005
Last verified: March 2005
The purpose of this study is to determine if transcranial magnetic stimulation at 1 HZ to the right frontal cortex will decrease the symptoms of post-traumatic stress disorder (PTSD).

Condition Intervention Phase
Post-Traumatic Stress Disorders Device: transcranial magnetic stimulation Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: A Prospective Double Blind Randomized Placebo Controlled Trial of Repetitive Transcranial Magnetic Stimulation for Posttraumatic Stress Disorder

Further study details as provided by White River Junction VAMC:

Primary Outcome Measures:
  • Clinician-Administered PTSD Scale (CAPS)

Secondary Outcome Measures:
  • PTSD Clinician Checklist (PCL)
  • Beck Depression Inventory (BDI)
  • State-Trait Anxiety Inventory (STAI)
  • Side Effect Checklist
  • Brief Cognitive Examination

Estimated Enrollment: 40
Study Start Date: March 2004
Detailed Description:

Post-traumatic stress disorder (PTSD) is a psychiatric disorder that is common in the general population. PTSD symptoms include re-experiencing the traumatic event, avoidance of reminders of the trauma, and increased arousal. The primary treatments of PTSD are psychotherapy and antidepressant medications. While both are effective, many patients continue to have significant symptoms. Repetitive Transcranial Magnetic Stimulation (rTMS) is a new research and treatment modality that uses a small powerful electromagnet to directly stimulate the brain. This stimulation may increase or decrease brain activity. The treatments have been shown to be effective in other disorders such as depression. Initial treatment of patients with PTSD using rTMS has been hopeful. This study is the first randomized controlled trial to examine the efficacy of rTMS for PTSD.

This study would be the first randomized placebo controlled trial to examine the efficacy of Transcranial Magnetic Stimulation (rTMS) for PTSD. The primary hypothesis is that there will be significant improvement in the patients' PTSD symptoms from pre-treatment to post-treatment with rTMS. A secondary hypothesis is that the patients’ co-morbid depressive symptoms will improve from pre-treatment to post-treatment. Forty subjects with PTSD will be recruited from the White River Junction VAMC. Patients will be randomly assigned to receive either active rTMS or sham rTMS. Patients, staff performing the treatments, and staff completing the assessments will all be blinded to active or sham treatment.


Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • PTSD diagnosis on standardized assessment
  • Medically stable
  • Eligible veteran of United States (US) military

Exclusion Criteria:

  • Active substance abuse
  • History of seizures
  • Metal in head or neck
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00134446

Contact: Bradley V Watts, MD 802-295-9363 ext 5688

United States, Vermont
White River Junction VAMC Recruiting
White River Junction, Vermont, United States, 05001
Contact: Bradley V Watts, MD    802-295-9363 ext 5688   
Principal Investigator: Bradley V Watts, MD         
Sponsors and Collaborators
White River Junction VAMC
Principal Investigator: Bradley V Watts, MD White River Junction VAMC
  More Information Identifier: NCT00134446     History of Changes
Other Study ID Numbers: WRJVAMC16744
Hitchcock Foundation
Study First Received: August 23, 2005
Last Updated: October 28, 2005

Keywords provided by White River Junction VAMC:
post traumatic stress disorder
transcranial magnetic stimulation
randomized clinical trial

Additional relevant MeSH terms:
Stress Disorders, Traumatic
Stress Disorders, Post-Traumatic
Pathologic Processes
Trauma and Stressor Related Disorders
Mental Disorders processed this record on July 27, 2017