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Proportional Ventilation and Ventilatory Synchronism

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified April 2007 by Hospices Civils de Lyon.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00133939
First Posted: August 24, 2005
Last Update Posted: April 27, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Hospices Civils de Lyon
  Purpose
Synchronism of gas flow delivered by the ventilator and muscular effort of the patient will be studied during two kinds of ventilation. The first one is the proportional assisted ventilation during which the gas flow is theoretically adapted to the patient's muscular effort within the breath. The second is the pressure support ventilation during which the gas flow is delivered to maintain the inspiratory pressure stable. The hypothesis is that the first mode allows a better synchronism.

Condition Intervention
Mechanical Ventilation Procedure: Mechanical ventilation

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Proportional Ventilation and Ventilatory Synchronism

Further study details as provided by Hospices Civils de Lyon:

Primary Outcome Measures:
  • Time lag between the onset of diaphragmatic electromyogram (EMG) signal and the zero crossing of the inspiratory flow, over five minutes

Secondary Outcome Measures:
  • Number per minute of failing breaths: breath with muscular effort without any inspiratory flow

Estimated Enrollment: 10
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients undergoing partial ventilatory support

Exclusion Criteria:

  • Patients failing the weaning process
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00133939


Contacts
Contact: Jean-Paul VIALE, MD, PhD 33 472 072 ext 426 jean-paul.viale@chu-lyon.fr

Locations
France
Hôpital de la Croix-Rousse Recruiting
Lyon, France, 69317
Contact: Jean-Paul VIALE, MD, PhD    33 472 072 ext 426    jean-paul.viale@chu-lyon.fr   
Principal Investigator: Jean-Paul VIALE, MD, PhD         
Sponsors and Collaborators
Hospices Civils de Lyon
Investigators
Principal Investigator: Jean-Paul VIALE, MD, PhD Hospices Civils de Lyon
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00133939     History of Changes
Other Study ID Numbers: 2004.359
First Submitted: August 23, 2005
First Posted: August 24, 2005
Last Update Posted: April 27, 2007
Last Verified: April 2007

Keywords provided by Hospices Civils de Lyon:
Proportional assisted ventilation
Pressure support ventilation
Synchronism during mechanical ventilation
Patients undergoing partial mechanical ventilation