MiniMUD Study - Unrelated Reduced Intensity Conditioning With Treosulfan® for Allogeneic Stem Cell Transplantation in Patients With Hematological Malignancies
Recruitment status was: Recruiting
In this study, treosulfan is evaluated for conditioning in allogenic stem cell transplantation. The procedure and the follow-up are the same as in standard allogenic transplant.
The donor is unrelated (identical HLA). The graft is haematological peripheral blood stem cell.
The conditioning with reduced intensity is: fludarabine (from day -6 to day -2), treosulfan (from day -6 to day -4) and thymoglobuline (from day -2 to day -1).
|Study Design:||Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Unrelated Reduced Intensity Conditioning With Treosulfan® for Allogeneic Stem Cell Transplantation in Patients With Hematological Malignancies|
- Overall survival at 1 year
- Engraftment evaluation
- Acute and chronic graft-versus-host disease incidence and severity
- Response rate and survival without progression
- Evaluation of conditioning and transplant toxicity
- Chimerism evaluation
|Study Start Date:||February 2005|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00129155
|Hôpital Edouard Herriot|
|Lyon, France, 69437|
|Principal Investigator:||Mauricette MICHALLET, MD||Hospices Civils de Lyon|