Trial of Pre-operative Chemoradiotherapy Followed by Surgical Resection in Pancoast Tumors (JCOG 9806)
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The purpose of this study is to evaluate the safety and efficacy of the trimodality (concurrent chemoradiotherapy followed by surgical resection) approach in superior sulcus tumors.
Condition or disease
Drug: mitomycin C, vindesine, cisplatin and radiotherapy
Pre-operative radiotherapy has long been the community standard in Pancoast, or superior sulcus tumor. However, both complete resection rate (-50%) and long-term survival (-30%) are poor and unchanged for 40 years. Concurrent chemoradiotherapy has been shown to be beneficial in unresectable stage III non-small cell cancer. Surgery after induction chemoradiotherapy thus is a promising treatment strategy, and in fact, SWOG reported favorable results of this trimodality approach in superior sulcus tumor. The current trial is a Japanese, cooperative, multi-center, prospective one to evaluate its safety and efficacy.
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Ages Eligible for Study:
15 Years to 74 Years (Child, Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Newly diagnosed, pathologically documented non-small cell lung cancer (NSCLC)
Invasion to the first rib or more superior chest wall
Age: 15-74 years old
Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
Ample organ function
No prior chemo- or radiotherapy
Signed informed consent
Metastasis to, or involvement of, mediastinal node (N2)
Distant metastasis or dissemination to pleura/pericardium