Vasopressin and Epinephrine Versus Epinephrine Alone in Cardiac Arrest

This study has been completed.
Information provided by:
Hospices Civils de Lyon Identifier:
First received: August 5, 2005
Last updated: October 16, 2007
Last verified: October 2007
Recent studies have suggested that arginine-vasopressin could be more effective in the treatment of cardiac arrests. The last published study did not outline obvious improvements in the prognosis of all cardiac arrests but pointed out a possible increased survival rate when arginine-vasopressin is associated with epinephrine. The aim of this study is to compare the efficacy of two successive injections of epinephrine (1 mg) with two successive injections of epinephrine associated with arginine-vasopressin (40 UI) in out-of-hospital cardiac arrests occurring in adult patients. The primary endpoint is the survival rate at hospital admission. The inclusion period lasts 18 months and 2416 patients are planned to be enrolled.

Condition Intervention Phase
Cardiac Arrest
Drug: epinephrine (1 mg/1 mL)
Drug: arginine-vasopressin (40 UI/2 mL)
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: Comparison of Epinephrine Associated With Vasopressin vs Epinephrine Alone in the Treatment of Out-of-Hospital Cardiac Arrests

Resource links provided by NLM:

Further study details as provided by Hospices Civils de Lyon:

Primary Outcome Measures:
  • Survival at hospital admission

Secondary Outcome Measures:
  • ROSC (Return of spontaneous circulation) Survival at : H24, Day 28, hospital discharge and one year Neurological status at H24 and hospital discharge.

Estimated Enrollment: 2416
Study Start Date: May 2004

Ages Eligible for Study:   18 Years to 85 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Out-of-hospital medical cardiac arrest in adult patients.

Exclusion Criteria:

  • Traumatic cardiac arrest
  • Pregnancy
  • Patients younger than 18 years old or older than 85 years old
  Contacts and Locations
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Please refer to this study by its identifier: NCT00127907

Centre Hospitalier Lyon Sud
Pierre Bénite, France, 69495
Sponsors and Collaborators
Hospices Civils de Lyon
Principal Investigator: Pierre-Yves GUEUGNIAUD, MD Hospices Civils de Lyon
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00127907     History of Changes
Other Study ID Numbers: 2003.329 
Study First Received: August 5, 2005
Last Updated: October 16, 2007
Health Authority: France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)

Keywords provided by Hospices Civils de Lyon:
Out-of-hospital cardiac arrest - Vasopressin - Epinephrine

Additional relevant MeSH terms:
Heart Arrest
Out-of-Hospital Cardiac Arrest
Cardiovascular Diseases
Heart Diseases
Arginine Vasopressin
Epinephryl borate
Adrenergic Agents
Adrenergic Agonists
Adrenergic alpha-Agonists
Adrenergic beta-Agonists
Anti-Asthmatic Agents
Antidiuretic Agents
Autonomic Agents
Bronchodilator Agents
Cardiovascular Agents
Hematologic Agents
Molecular Mechanisms of Pharmacological Action
Natriuretic Agents
Neurotransmitter Agents
Peripheral Nervous System Agents
Pharmacologic Actions
Physiological Effects of Drugs
Respiratory System Agents
Sympathomimetics processed this record on April 27, 2016