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Effect of Glutathione on Blood Alcohol and Hangover Symptoms

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00127309
First Posted: August 5, 2005
Last Update Posted: December 9, 2005
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
T.C Union Global Plc.
Information provided by:
Piyavate Hospital
  Purpose

Glutathione (a tripeptide of 3 amino acids - glutamic acid, cysteine and glycine) plays a great role in homeostasis, especially as a potent anti-oxidant.

As an anti-oxidant, it conjugates with xenobiotics using glutathione-S-transferase (GST) and excretes in urine as mercapturic acid.

In 1986, Casciani et al at the University of Milan, studied the effect of glutathione on blood alcohol, acetaldehyde and hepatic triglyceride levels and found a significant reducing effect.

The blood acetaldehyde, which is the metabolic product of ethyl alcohol may have a correlation with hangover symptoms. This study is designed to find this correlation using blood alcohol, blood acetaldehyde levels and the Hangover Symptoms Scale according to the Slutske et al study.


Condition Intervention
Alcohol Drinking Drug: Glutathione

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment

Resource links provided by NLM:

MedlinePlus related topics: Alcohol
Drug Information available for: Glutathione
U.S. FDA Resources

Further study details as provided by Piyavate Hospital:
Estimated Enrollment: 100
Study Start Date: June 2005
Estimated Study Completion Date: August 2005
  Show Detailed Description

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy
  • Males 20-40 years old
  • No allergies to alcohol

Exclusion Criteria:

  • Chronic disease
  • Increase in hepatic enzyme SGPT
  • Impending danger
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00127309


Locations
Thailand
Piyavate Hospital
Bangkok, Thailand, 10320
Sponsors and Collaborators
Piyavate Hospital
T.C Union Global Plc.
Investigators
Principal Investigator: Staporn Jinaratana, M.D Piyavate Hospital
  More Information

Publications:
L. Casciani et al.,Effect of GSH on hepatic triglyceride levels at different times after ethanol intoxification IRSC Med.Sci.,vol.14,158(1986)

ClinicalTrials.gov Identifier: NCT00127309     History of Changes
Other Study ID Numbers: sj_1
First Submitted: August 4, 2005
First Posted: August 5, 2005
Last Update Posted: December 9, 2005
Last Verified: July 2005

Keywords provided by Piyavate Hospital:
hangover
hangover symptoms

Additional relevant MeSH terms:
Alcohol Drinking
Drinking Behavior