Effect of Glutathione on Blood Alcohol and Hangover Symptoms
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|ClinicalTrials.gov Identifier: NCT00127309|
Recruitment Status : Completed
First Posted : August 5, 2005
Last Update Posted : August 24, 2005
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Glutathione (a tripeptide of 3 amino acids - glutamic acid, cysteine and glycine) plays a great role in homeostasis, especially as a potent anti-oxidant.
As an anti-oxidant, it conjugates with xenobiotics using glutathione-S-transferase (GST) and excretes in urine as mercapturic acid.
In 1986, Casciani et al at the University of Milan, studied the effect of glutathione on blood alcohol, acetaldehyde and hepatic triglyceride levels and found a significant reducing effect.
The blood acetaldehyde, which is the metabolic product of ethyl alcohol may have a correlation with hangover symptoms. This study is designed to find this correlation using blood alcohol, blood acetaldehyde levels and the Hangover Symptoms Scale according to the Slutske et al study.
|Condition or disease||Intervention/treatment||Phase|
|Alcohol Drinking||Drug: Glutathione||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||100 participants|
|Intervention Model:||Parallel Assignment|
|Study Start Date :||June 2005|
|Study Completion Date :||August 2005|
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|Ages Eligible for Study:||20 Years to 40 Years (Adult)|
|Sexes Eligible for Study:||Male|
|Accepts Healthy Volunteers:||Yes|
- Males 20-40 years old
- No allergies to alcohol
- Chronic disease
- Increase in hepatic enzyme SGPT
- Impending danger
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00127309
|Bangkok, Thailand, 10320|
|Principal Investigator:||Staporn Jinaratana, M.D||Piyavate Hospital|
|Other Study ID Numbers:||
|First Posted:||August 5, 2005 Key Record Dates|
|Last Update Posted:||August 24, 2005|
|Last Verified:||July 2005|