Effect of Glutathione on Blood Alcohol and Hangover Symptoms

This study has been completed.

Sponsor:

Collaborator:

T.C Union Global Plc.

Information provided by:

Piyavate Hospital

ClinicalTrials.gov Identifier:

NCT00127309

First received: August 4, 2005

Last updated: August 23, 2005

Last verified: July 2005

History of Changes

Purpose

Glutathione (a tripeptide of 3 amino acids - glutamic acid, cysteine and glycine) plays a great role in homeostasis, especially as a potent anti-oxidant.

As an anti-oxidant, it conjugates with xenobiotics using glutathione-S-transferase (GST) and excretes in urine as mercapturic acid.

In 1986, Casciani et al at the University of Milan, studied the effect of glutathione on blood alcohol, acetaldehyde and hepatic triglyceride levels and found a significant reducing effect.

The blood acetaldehyde, which is the metabolic product of ethyl alcohol may have a correlation with hangover symptoms. This study is designed to find this correlation using blood alcohol, blood acetaldehyde levels and the Hangover Symptoms Scale according to the Slutske et al study.

Condition	Intervention
Alcohol Drinking	Drug: Glutathione


Study Type:	Interventional
Study Design:	Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double-Blind Primary Purpose: Treatment

Resource links provided by NLM:

Drug Information available for: Glutathione

U.S. FDA Resources

Further study details as provided by Piyavate Hospital:


Estimated Enrollment:	100
Study Start Date:	June 2005
Estimated Study Completion Date:	August 2005

Show Detailed Description

Eligibility


Ages Eligible for Study:	20 Years to 40 Years (Adult)
Genders Eligible for Study:	Male
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Healthy
Males 20-40 years old
No allergies to alcohol

Exclusion Criteria:

Chronic disease
Increase in hepatic enzyme SGPT
Impending danger

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00127309

Locations


Thailand
Piyavate Hospital
Bangkok, Thailand, 10320

Sponsors and Collaborators

Piyavate Hospital

T.C Union Global Plc.

Investigators


Principal Investigator:	Staporn Jinaratana, M.D	Piyavate Hospital

More Information

Publications:

L. Casciani et al.,Effect of GSH on hepatic triglyceride levels at different times after ethanol intoxification IRSC Med.Sci.,vol.14,158(1986)


ClinicalTrials.gov Identifier:	NCT00127309 History of Changes
Other Study ID Numbers:	sj_1
Study First Received:	August 4, 2005
Last Updated:	August 23, 2005
Health Authority:	Thailand: Food and Drug Administration

Keywords provided by Piyavate Hospital:


hangover hangover symptoms

Additional relevant MeSH terms:


Alcohol Drinking Drinking Behavior

ClinicalTrials.gov processed this record on September 29, 2016

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