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Effect of Glutathione on Blood Alcohol and Hangover Symptoms

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00127309
Recruitment Status : Completed
First Posted : August 5, 2005
Last Update Posted : August 24, 2005
T.C Union Global Plc.
Information provided by:
Piyavate Hospital

Brief Summary:

Glutathione (a tripeptide of 3 amino acids - glutamic acid, cysteine and glycine) plays a great role in homeostasis, especially as a potent anti-oxidant.

As an anti-oxidant, it conjugates with xenobiotics using glutathione-S-transferase (GST) and excretes in urine as mercapturic acid.

In 1986, Casciani et al at the University of Milan, studied the effect of glutathione on blood alcohol, acetaldehyde and hepatic triglyceride levels and found a significant reducing effect.

The blood acetaldehyde, which is the metabolic product of ethyl alcohol may have a correlation with hangover symptoms. This study is designed to find this correlation using blood alcohol, blood acetaldehyde levels and the Hangover Symptoms Scale according to the Slutske et al study.

Condition or disease Intervention/treatment Phase
Alcohol Drinking Drug: Glutathione Not Applicable

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Study Type : Interventional  (Clinical Trial)
Enrollment : 100 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
Study Start Date : June 2005
Study Completion Date : August 2005

Resource links provided by the National Library of Medicine

Drug Information available for: Glutathione

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy
  • Males 20-40 years old
  • No allergies to alcohol

Exclusion Criteria:

  • Chronic disease
  • Increase in hepatic enzyme SGPT
  • Impending danger

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00127309

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Piyavate Hospital
Bangkok, Thailand, 10320
Sponsors and Collaborators
Piyavate Hospital
T.C Union Global Plc.
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Principal Investigator: Staporn Jinaratana, M.D Piyavate Hospital
L. Casciani et al.,Effect of GSH on hepatic triglyceride levels at different times after ethanol intoxification IRSC Med.Sci.,vol.14,158(1986)

Layout table for additonal information Identifier: NCT00127309    
Other Study ID Numbers: sj_1
First Posted: August 5, 2005    Key Record Dates
Last Update Posted: August 24, 2005
Last Verified: July 2005
Keywords provided by Piyavate Hospital:
hangover symptoms
Additional relevant MeSH terms:
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Alcohol Drinking
Drinking Behavior