Health Effects of Diesel Exhaust in Asthmatic Patients: A Real-world Study in a London Street
Acute exposure to diesel exhaust under normal city conditions leads to a worsening of symptoms of asthma, with reduction in lung function in asthmatic nonsmoking adults, dependent on the exposure dose and on the background severity of asthma.
The worsening asthma is accompanied by increased oxidative stress and inflammation in the lungs.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Health Effects of Diesel Exhaust in Asthmatic Patients: A Real-world Study in a London Street|
- Spirometry [ Time Frame: During exposure and 24 hours after ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
Exhaled breath condensate
|Study Start Date:||May 2003|
|Study Completion Date:||August 2006|
|Primary Completion Date:||August 2006 (Final data collection date for primary outcome measure)|
Asthma patients ranging from mild to severe
|Healthy Non-Smokers||Other: Exposure|
The investigators will recruit 60 nonsmoking asthmatics of mild and of moderate severity. They will be exposed to Oxford St. or to Hyde Park for 2 hours each, at a walking pace. Real time exposure to PM2.5, carbon monoxide and nitrogen dioxide will be made each time. Health outcome measurements will be made before and after exposure to each street. Statistical analyses will be made to examine the effect of diesel exposure on changes in health outcome measures.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00127062
|Principal Investigator:||Paul Cullinan, MD||Imperial College London|
|Study Director:||Fan Chung, MD||Imperial College London|
|Principal Investigator:||Mark Nieuwenhuijsen, PhD||Imperial College London|
|Principal Investigator:||Jim Zhang, PhD||Rutgers U & UMDNJ|