Health Effects of Diesel Exhaust in Asthmatic Patients: A Real-world Study in a London Street
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|ClinicalTrials.gov Identifier: NCT00127062|
Recruitment Status : Completed
First Posted : August 5, 2005
Last Update Posted : March 26, 2015
Acute exposure to diesel exhaust under normal city conditions leads to a worsening of symptoms of asthma, with reduction in lung function in asthmatic nonsmoking adults, dependent on the exposure dose and on the background severity of asthma.
The worsening asthma is accompanied by increased oxidative stress and inflammation in the lungs.
|Condition or disease||Intervention/treatment|
|Study Type :||Observational|
|Enrollment :||60 participants|
|Official Title:||Health Effects of Diesel Exhaust in Asthmatic Patients: A Real-world Study in a London Street|
|Study Start Date :||May 2003|
|Actual Primary Completion Date :||August 2006|
|Actual Study Completion Date :||August 2006|
Asthma patients ranging from mild to severe
- Spirometry [ Time Frame: During exposure and 24 hours after ]
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00127062
|Principal Investigator:||Paul Cullinan, MD||Imperial College London|
|Study Director:||Fan Chung, MD||Imperial College London|
|Principal Investigator:||Mark Nieuwenhuijsen, PhD||Imperial College London|
|Principal Investigator:||Jim Zhang, PhD||Rutgers U & UMDNJ|