Quality of Life of Adult Cancer Survivors Who Have Undergone a Previous Bone Marrow or Peripheral Stem Cell Transplant for a Childhood Hematologic Cancer
RATIONALE: Studying quality of life in cancer survivors may help determine the long-term effects of hematologic cancer and may help improve the quality of life for future cancer survivors.
PURPOSE: This clinical trial is studying the quality of life of adult cancer survivors who have undergone a previous bone marrow or peripheral stem cell transplant for a childhood hematologic cancer.
|Leukemia Lymphoma Myelodysplastic Syndromes Quality of Life||Procedure: cognitive assessment Procedure: management of therapy complications Procedure: psychosocial assessment and care Procedure: quality-of-life assessment||Phase 2|
|Official Title:||The Quality of Life of Adult Survivors Who Received a Marrow Transplant as a Child|
- Neuroendocrine status of disease-free childhood transplant patients at 5 years after transplant and ≥ age 18
- Cognitive capability of disease-free childhood transplant patients at 5 years after transplant and ≥ age 18
- Physical capability of disease-free childhood transplant patients at 5 years after transplant and ≥ age 18
- Psychosocial status of disease-free childhood transplant patients at 5 years after transplant and ≥ age 18
|Study Start Date:||March 1996|
|Study Completion Date:||March 2010|
|Primary Completion Date:||April 2007 (Final data collection date for primary outcome measure)|
- Determine the extent to which adult cancer survivors who have undergone prior bone marrow or peripheral blood stem cell transplantation for a pediatric hematologic malignancy require ongoing health care and whether these needs change with increasing time after transplantation.
- Correlate physical capabilities, body image, physical limitations, including sexuality issues which alter or influence lifestyle, with time after transplantation in these patients.
- Determine whether cognitive abilities relative to memory and neurobehavioral ratings change with increasing time after transplantation in these patients.
- Correlate social and relationship abilities with length of time after transplantation in these patients.
OUTLINE: Patients and siblings complete a self-report quality of life questionnaire, including outcome assessments of neuroendocrine function, cognitive abilities, physical capability, and psychosocial behavior.
PROJECTED ACCRUAL: Approximately 750 patients (375 adult cancer survivors [case group] and 375 siblings [control group]) will be accrued for this study within 7 years.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00126477
|United States, Washington|
|Fred Hutchinson Cancer Research Center|
|Seattle, Washington, United States, 98109-1024|
|Principal Investigator:||Jean E. Sanders, MD||Fred Hutchinson Cancer Research Center|