Bioavailability and Effectiveness of Transdermally Administered Morphine
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Patients will participate in two arms of the trial, one in which morphine will be administered transdermally, and, after a 3 day wash out period, one in which morphine will be administered subcutaneously.
Condition or disease
Patients will participate in two arms of the trial, one in which morphine will be administered transdermally, and, after a 3 day wash out period, one in which morphine will be administered subcutaneously. Blood draws will be done after both dosing methods in order to compare blood levels of morphine by the different routes.
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Ages Eligible for Study:
18 Years to 65 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Chronic cancer pain
Minimum baseline pain of 3/10
No change in medications over 3 days prior to study period
Ability to give informed consent
Willingness to undergo repeated blood sampling
Use of morphine or codeine in 3 days prior to study