A Change in Diet May Decrease the Negative Consequences of Chronic Sleep Deprivation

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00123214
Recruitment Status : Completed
First Posted : July 22, 2005
Last Update Posted : June 27, 2006
Inflammation Research Foundation, Marblehead, MA.
NeuroScience, Inc., Osceola, WI.
Information provided by:
St. Vincent's Medical Center

Brief Summary:
The purpose of this study is to determine whether or not a low calorie, low glycemic index diet with omega-3 fatty acid supplements can prevent some of the negative consequences of sleep deprivation.

Condition or disease Intervention/treatment Phase
Sleep Deprivation Drug: Controlled Dietary Intervention Not Applicable

Detailed Description:

This pilot study included 18 medical residents at two academic medical centers in New York City. All residents who participated in the study were assigned to work a night shift schedule for two weeks, and began the study on the morning prior to their first evening shift. The study subjects were randomly assigned to one of two groups:

  • Intervention diet -- consisting of 40% carbohydrates, 30% protein, and 30% fat with 2.4g of long chain fatty acid supplements (n=9) Total calories for males was 1600/day, and 1200/day for females
  • Control group -- ad lib diet.

Main outcome measures included:

  • weight
  • resting metabolic rate
  • percent body fat
  • lipid profile
  • CRP
  • fasting glucose and insulin levels
  • urinary neurotransmitter levels
  • salivary cortisol
  • six cognitive tests of memory, attention, and executive function.

Subjects were tested on day 1, 7, and 14 of the study.

Study Type : Interventional  (Clinical Trial)
Enrollment : 18 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single
Primary Purpose: Prevention
Official Title: Pilot Study: A Dietary Intervention May Decrease the Negative Metabolic and Cognitive Consequences of Chronic Sleep Deprivation
Study Start Date : September 2004
Study Completion Date : April 2005

Primary Outcome Measures :
  1. Resting Metabolic Rate

Secondary Outcome Measures :
  1. Weight
  2. Percent Body Fat
  3. Waist Circumference
  4. Lipid Profile
  5. C-reactive Protein Levels
  6. Fasting serum glucose
  7. Fasting serum insulin
  8. Urinary neurotransmitter levels
  9. Salivary a.m. cortisol levels
  10. Cognitive scores on: Stroop Test, Hopkins Verbal Learning Test, Trail Making Test, Digit Span, Block Design, Dynamic Visual Acuity, Short Form 36

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Ages Eligible for Study:   25 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Medical resident in good standing at Cabrini Medical Center or Saint Vincent's Hospital, NY.
  • Must be scheduled for two consecutive weeks of night shift work.

Exclusion Criteria:

  • Febrile illness
  • Smoker
  • Food allergies of any kind
  • Taking any prescription medication
  • History of diabetes or thyroid dysfunction
  • Body mass index (BMI)>30
  • Pregnancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00123214

United States, New York
Saint Vincent's Hospital
New York, New York, United States, 10011
Sponsors and Collaborators
St. Vincent's Medical Center
Inflammation Research Foundation, Marblehead, MA.
NeuroScience, Inc., Osceola, WI.
Principal Investigator: Valerie A Jones, MD Saint Vincent's Hospital, Manhattan
Study Director: Steven M Lascher, DVM Saint Vincent's Hospital, Manhattan

Additional Information: Identifier: NCT00123214     History of Changes
Other Study ID Numbers: IRB 77-04
First Posted: July 22, 2005    Key Record Dates
Last Update Posted: June 27, 2006
Last Verified: July 2005

Keywords provided by St. Vincent's Medical Center:
Chronic sleep deprivation
Cognitive impairment
Resting metabolic rate
Weight Gain
Percent Body Fat

Additional relevant MeSH terms:
Sleep Deprivation
Sleep Wake Disorders
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Mental Disorders