Folic Acid Supplementation in Gambian Primigravidae
Supplementation with folic acid and iron is recommended for pregnant women in order to prevent them from developing anemia. In malaria endemic areas of Africa, the World Health Organization (WHO) now recommends that pregnant women should also be given sulfadoxine-pyrimethamine (SP) once a month after quickening to protect them against malaria which is especially harmful during pregnancy. However, folic acid is an antagonist of SP so there is a possibility that giving folic acid with SP could interfere with the ability of the latter to provide protection against malaria. To investigate this possibility Gambian primigravidae with malaria parasitemia have been given SP and folic acid at the same time or on separate occasions two weeks apart and the ability of SP to cure the malaria infection investigated.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Primary Purpose: Prevention
|Official Title:||A Study of the Effect of Folic Acid Supplementation on the Anti-Malarial Action of Sulfadoxine-Pyrimethamine When Used for Intermittent Preventive Treatment in Gambian Primigravidae.|
- Clearance of malaria parasitemia in parasitemic pregnant women 14 days after treatment with sulfadoxine-pyrimethamine.
- The prevalence of malaria parasitemia 14 days after administration of a dose of sulfadoxine-pyrimethamine to pregnant women.
- The mean haemoglobin 14 days after administration of a single dose of sulfadoxine-pyrimethamine to pregnant women.
|Study Start Date:||July 2002|
|Estimated Study Completion Date:||January 2004|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00120822
|Medical Research Council, Laboratories|
|Banjul, Gambia, PO Box 273|
|Study Chair:||Brian Greenwood, MD||London School of Hygiene and Tropical Medicine|