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Evaluation of Acetabular Perfusion After Ganz Osteotomy by Positron Emission Tomography

This study has been completed.
Information provided by (Responsible Party):
University of Aarhus Identifier:
First received: July 5, 2005
Last updated: November 19, 2015
Last verified: September 2009
The purpose of this study is to examine the blood flow in acetabulum after periacetabular osteotomy by Positron Emission Tomography (PET).

Condition Intervention
Procedure: Periacetabular osteotomy

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Evaluation of Acetabular Perfusion After Ganz Osteotomy by Positron Emission Tomography

Further study details as provided by University of Aarhus:

Primary Outcome Measures:
  • changes in blood flow [ Time Frame: within the first three weeks after operation ]

Secondary Outcome Measures:
  • fluoride uptake [ Time Frame: within the first three weeks after operation ]

Enrollment: 12
Study Start Date: January 2004
Study Completion Date: August 2009
Primary Completion Date: January 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
periacetabular osteotomy Procedure: Periacetabular osteotomy
osteotomy of the pelvis to increase acetabular coverage
Other Name: PAO

Detailed Description:

As a consequence of periacetabular osteotomy the blood flow in acetabulum is decreased. After periacetabular osteotomy has been performed there is fine contact between the osteotomised acetabulum and the rest of the pelvis and the potential for healing is good. However, it has not been investigated how much the blood flow in acetabulum is changed after surgery. The blood flow is considered to be vital for how the pelvis heals after surgery. Most likely, the blood flow is important in relation to which degree osteoarthritis can be prevented after periacetabular osteotomy.

It is possible to estimate the blood flow by Positron Emission Tomography of the dysplastic hip joint pre- and postoperatively. In this study the blood flow and fluoride uptake is quantified by Positron emission tomography based on measurements of O-15 water and F-18 fluoride.


Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients with radiologically diagnosed hip dysplasia (CE-angle < 25°).
  • Patients with osteoarthritis graded 0, 1 or 2 defined according to Tönnis' classification. Patients with pain from hip
  • Age > 18 years.
  • Minimum 110° flexion in hip joint and closed growth zones in the pelvic.
  • Informed consent.

Exclusion Criteria:

  • Patients with neurological diseases
  • Patients with calvé-Legg-Perthes syndrome.
  • Patients where an femoral intertrochanteric osteotomy is necessary.
  • Patients with medical sequelae after earlier hip surgery.
  • Females who are pregnant.
  • Patients with metal implants.
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Please refer to this study by its identifier: NCT00119444

Orthopaedic Center, Aarhus University Hospital
Aarhus, Denmark, 8000
Sponsors and Collaborators
University of Aarhus
Principal Investigator: Kjeld Søballe, MD, Prof. Orthopaedic Center, Aarhus University Hospital, Aarhus, Denmark
  More Information

Responsible Party: University of Aarhus Identifier: NCT00119444     History of Changes
Other Study ID Numbers: 20050606
Study First Received: July 5, 2005
Last Updated: November 19, 2015

Keywords provided by University of Aarhus:
Periacetabular osteotomy

Additional relevant MeSH terms:
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases processed this record on April 26, 2017