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Vaccination in the Peripheral Stem Cell Transplant Setting for Multiple Myeloma

This study has been completed.
Information provided by:
Cell Genesys Identifier:
First received: June 29, 2005
Last updated: December 18, 2007
Last verified: December 2007
The purpose of this study is to evaluate the safety and efficacy of vaccination with autologous myeloma cells and an allogeneic granulocyte-macrophage colony stimulating factor (GM-CSF) producing cell line.

Condition Intervention Phase
Multiple Myeloma
Biological: Therapeutic Cellular Vaccine, GM-CSF Producing
Phase 1
Phase 2

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Vaccination in the Peripheral Stem Cell Transplant Setting for Multiple Myeloma: The Use of Autologous Tumor Cells With an Allogeneic GM-CSF Producing Cell Line

Resource links provided by NLM:

Further study details as provided by Cell Genesys:

Primary Outcome Measures:
  • Multiple myeloma

Estimated Enrollment: 22
Study Start Date: October 2000
Estimated Study Completion Date: October 2004

Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • De novo multiple myeloma
  • ECOG 0-2
  • No serious co-morbid illnesses and adequate organ function
  • > 4 weeks from systemic steroids

Exclusion Criteria:

  • No existing secondary malignancies and no history of secondary malignancies in the past 5 years
  • No active autoimmune disease
  Contacts and Locations
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Please refer to this study by its identifier: NCT00116441

United States, Maryland
Johns Hopkins University
Baltimore, Maryland, United States, 21231
Sponsors and Collaborators
Cell Genesys
  More Information Identifier: NCT00116441     History of Changes
Other Study ID Numbers: K-0007
Study First Received: June 29, 2005
Last Updated: December 18, 2007

Keywords provided by Cell Genesys:
Multiple Myeloma
Peripheral Stem Cell Transplant

Additional relevant MeSH terms:
Multiple Myeloma
Neoplasms, Plasma Cell
Neoplasms by Histologic Type
Hemostatic Disorders
Vascular Diseases
Cardiovascular Diseases
Blood Protein Disorders
Hematologic Diseases
Hemorrhagic Disorders
Lymphoproliferative Disorders
Immunoproliferative Disorders
Immune System Diseases processed this record on April 26, 2017