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Trial of IV Injection of CV787 in Hormone Refractory Metastatic Prostate Cancer

This study has been completed.
Information provided by:
Cell Genesys Identifier:
First received: June 27, 2005
Last updated: NA
Last verified: June 2005
History: No changes posted
This is a multi-center, open-label, dose finding study of CV787 adenovirus in patients with hormone refractory metastatic prostate cancer. Patients will receive treatment intravenously at one of up to nine dose levels, each containing three to six patients.

Condition Intervention Phase
Prostate Cancer Biological: CV787 (CG7870) Phase 1 Phase 2

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Phase I/II Dose Finding Trial of the Intravenous Injection of CV787, a Prostate-Specific Antigen Cytolytic Adenovirus, in Patients With Hormone Refractory Metastatic Prostate Cancer

Resource links provided by NLM:

Further study details as provided by Cell Genesys:

Primary Outcome Measures:
  • To determine the safety, tolerability, and the maximum tolerated dose of CG7870 when administered intravenously to patients with progressive metastatic hormone refractory prostate cancer

Secondary Outcome Measures:
  • To evaluate prostate-specific antigen (PSA) response rates, duration of response, and time to disease progression
  • To evaluate other clinical efficacy responses observed
  • To evaluate the systemic pharmacokinetics of CG7870 after intravenous administration
  • To monitor the immune response to CG7870


Ages Eligible for Study:   Child, Adult, Senior
  Contacts and Locations
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No Contacts or Locations Provided
  More Information Identifier: NCT00116155     History of Changes
Other Study ID Numbers: CV787-9902
Study First Received: June 27, 2005
Last Updated: June 27, 2005

Keywords provided by Cell Genesys:
Hormone Refractory Metastatic Prostate Cancer

Additional relevant MeSH terms:
Prostatic Neoplasms
Genital Neoplasms, Male
Urogenital Neoplasms
Neoplasms by Site
Genital Diseases, Male
Prostatic Diseases
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs processed this record on August 21, 2017