Inflammatory Profiles of Children at High Risk for Atherosclerosis
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|ClinicalTrials.gov Identifier: NCT00115232|
Recruitment Status : Completed
First Posted : June 22, 2005
Last Update Posted : January 16, 2008
|Condition or disease|
|Cardiovascular Disease Metabolic Syndrome X Hypercholesterolemia Inflammation|
Family history is a well known risk factor for early atherosclerosis. Whether inflammation plays a role in the increased risk of family history is not known. In this prospective single-center study, we are recruiting children with and without a family history of premature atherosclerotic disease, defined as occurring < 55 years in males and <65 years in females. Children are recruited primarily from a pediatric preventive cardiology clinic at Children's Hospital Boston. We measure anthropomorphic characteristics, fasting lipid profiles and inflammatory marker levels, including high sensitivity C-reactive protein (hsCRP), intracellular adhesion molecule 1 (ICAM-1), P-selectin, and tumor necrosis factor alpha receptor 2 (TNFαR2).
In this sample of high-risk overweight children, Lp(a) and inflammatory markers could reflect cardiovascular risk outside lipid profiles.
|Study Type :||Observational|
|Actual Enrollment :||300 participants|
|Official Title:||Inflammatory Profiles of Children at High Risk for Atherosclerosis|
|Study Start Date :||July 2004|
|Actual Primary Completion Date :||October 2006|
|Actual Study Completion Date :||March 2007|
Children without family history of early atherosclerosis
Children with family history of early atherosclerosis.
Parents of children without family history of early atherosclerosis
Parents of children with family history of early atherosclerosis
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00115232
|United States, Massachusetts|
|Children's Hospital Boston|
|Boston, Massachusetts, United States, 02115|
|Principal Investigator:||Sarah D. de Ferranti, MD MPH||Boston Children’s Hospital|