Sensory Examination and Pharmacological Modulation of Oral Hyperexcitability in Patients With Atypical Odontalgia and Matched Healthy Controls

This study has been completed.
Danish Pain Research Center
Information provided by:
University of Aarhus Identifier:
First received: June 20, 2005
Last updated: June 15, 2006
Last verified: June 2006
This project examines experimental pain and chronic pain in the mouth, specifically the condition called atypical odontalgia (AO:atypical toothpain). In 16 patients with AO and 16 healthy persons, capsaicin (chili-pepper) is applied to the gingiva to cause pain. This pain is evaluated by the participants. In three sessions, 3 different medications are tested for effect on the pain. The medications are fentanyl, S-ketamine and placebo-treatment (saline). The aim is to know more about pain mechanisms in AO in order to develop an effective treatment.

Condition Intervention Phase
Drug: fentanyl
Drug: S-ketamine
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double-Blind
Primary Purpose: Diagnostic

Further study details as provided by University of Aarhus:

Primary Outcome Measures:
  • Pain
  • Sensitivity to heat and cold
  • Sensitivity to mechanical stimuli

Estimated Enrollment: 20
Study Start Date: March 2004
Estimated Study Completion Date: October 2005

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Atypical odontalgia

Exclusion Criteria:

  • BMI > 30
  • Heart conditions
  • Lung disease
  • Diseases of the liver or kidneys
  • Hypertension, untreated
  Contacts and Locations
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Please refer to this study by its identifier: NCT00115102

Danish Pain Research Center
Aarhus, Denmark, DK-8000
Sponsors and Collaborators
University of Aarhus
Danish Pain Research Center
Study Chair: Troels Staehelin Jensen, MD, PhD, Dr.Sci Aarhus University Hospital
  More Information Identifier: NCT00115102     History of Changes
Other Study ID Numbers: AO1 
Study First Received: June 20, 2005
Last Updated: June 15, 2006
Health Authority: Denmark: Danish Medicines Agency

Keywords provided by University of Aarhus:
Atypical odontalgia
neuropathic pain

Additional relevant MeSH terms:
Facial Pain
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Stomatognathic Diseases
Tooth Diseases processed this record on May 26, 2016