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Hypertonic Saline With Dextran for Treating Hypovolemic Shock and Severe Brain Injury

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ClinicalTrials.gov Identifier: NCT00113685
Recruitment Status : Completed
First Posted : June 10, 2005
Last Update Posted : May 3, 2021
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
Eileen Bulger, University of Washington

Brief Summary:
The purpose of this study is to evaluate the clinical outcome of patients following blunt traumatic injury with hypovolemic shock, who receive either lactated ringer's solution or hypertonic saline with dextran (HSD) resuscitation; also, to focus specifically on neurologic outcome in patients with brain injury and on the effect of HSD resuscitation on inflammatory cell responsiveness.

Condition or disease Intervention/treatment Phase
Respiratory Distress Syndrome, Adult Head Injuries, Closed Shock Shock, Traumatic Drug: Hypertonic Saline-Dextran Solution Drug: Lactated Ringer's Solution Not Applicable

Detailed Description:


Trauma is the leading cause of death among Americans between the ages of 1 and 35 years. The majority of these deaths result from hypovolemic shock, a type of shock in which the heart is unable to supply enough blood to the body, and the resulting severe brain injury. Patients in hypovolemic shock develop a state of systemic tissue ischemia with a subsequent reperfusion injury at the time of fluid resuscitation. Conventional resuscitation of these patients involves the intravenous administration of a large volume of isotonic or slightly hypotonic (lactated ringers) solutions beginning in the pre-hospital environment. Previous studies have suggested that an alternative resuscitation fluid, HSD, may reduce mortality in these patients; but these studies have not been conclusive. Furthermore, HSD may have specific advantages in the brain-injured patient, as it may aid in the rapid restoration of cerebral perfusion, prevent extravascular fluid sequestration, and thus, limit secondary brain injury. In addition, recent studies have demonstrated that hypertonicity significantly alters the activation of inflammatory cells, which may result in a reduction in subsequent organ injury following whole body ischemia/reperfusion and ultimately decrease nosocomial infection rates.

Blunt trauma victims with low blood pressures will be identified by pre-hospital providers (paramedics and flight nurses) and randomized to receive either 250 cc of HSD or 250 cc of isotonic solution (lactated ringer's solution). Lactated ringer's solution is the current standard of care with which the ambulances and helicopters will be supplied. All bags of study solution will be prepared by the Harborview Medical Center pharmacy.


This randomized clinical trial seeks to evaluate the clinical outcome and inflammatory cell function of patients in shock following blunt traumatic injury who are randomized to receive either 7.5% hypertonic saline/6% dextran (HSD) followed by lactated ringer's solution or lactated ringer's solution alone. It is hypothesized that HSD resuscitation will inhibit the initial excessive systemic activation of the inflammatory response, which will translate into a reduction in the incidence of organ dysfunction typically induced by this response. Furthermore, the study will evaluate the impact of HSD resuscitation on recovery following traumatic brain injury, as previous studies suggest that this subgroup has the greatest survival advantage from HSD intervention. The specific aims for this study include the following: Aim 1: To determine the impact of pre-hospital administration of HSD on the development of organ failure following blunt traumatic injury with hypovolemic shock. Aim 2: To determine the impact of pre-hospital administration of HSD on the neurologic outcome following brain injury for patients in hypovolemic shock. Aim 3a: To determine the effect of pre-hospital administration of HSD on the activation of circulating neutrophils and monocytes. Aim 3b: To determine the effect of pre-hospital administration of HSD on the activation of T lymphocytes. The study builds upon previous research that has demonstrated the safety and practicality of this resuscitation strategy in the pre-hospital environment. A more detailed understanding of the immuno-inflammatory effects of hypertonicity for all patients and the long-term neurologic outcome for patients with brain injury is critical for determining the role of this resuscitation approach in such critically injured patients.

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Study Type : Interventional  (Clinical Trial)
Enrollment : 209 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: Effect of Hypertonic Resuscitation for Blunt Trauma
Study Start Date : April 2003
Study Completion Date : March 2007

Primary Outcome Measures :
  1. Adult respiratory distress syndrome symptoms (measured 28 days post-injury)

Secondary Outcome Measures :
  1. Multiple organ failure syndrome
  2. 28 day mortality
  3. Nosocomial infections
  4. Duration of hospital and ICU stay
  5. Duration of mechanical ventilation
  6. Neurologic outcome for patients with traumatic brain injury based on the Glasgow Outcome Score and Disability Rating Score (measured at 6 and 12 months post-injury)

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Recent blunt trauma
  • Of adult size if age is unknown
  • Pre-hospital systolic bloood pressure 90 mm Hg or less
  • Altered mental status
  • Transported directly to Harborview Medical Center from the injury event

Exclusion Criteria:

  • Ongoing CPR
  • Transferred from outside hospitals
  • Pregnant or suspected pregnancy
  • Presence of injuries from penetrating trauma
  • Receiving more than 2000 cc of crystaloid prior to study fluid administration

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00113685

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United States, Washington
University of Washington
Seattle, Washington, United States, 98104-2499
Sponsors and Collaborators
University of Washington
National Heart, Lung, and Blood Institute (NHLBI)
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Study Chair: Eileen Bulger University of Washington
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Eileen Bulger, Professor, School of Medicine, University of Washington
ClinicalTrials.gov Identifier: NCT00113685    
Other Study ID Numbers: 20737
R01HL073233 ( U.S. NIH Grant/Contract )
First Posted: June 10, 2005    Key Record Dates
Last Update Posted: May 3, 2021
Last Verified: April 2021
Additional relevant MeSH terms:
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Respiratory Distress Syndrome
Respiratory Distress Syndrome, Newborn
Acute Lung Injury
Craniocerebral Trauma
Head Injuries, Closed
Shock, Traumatic
Wounds and Injuries
Pathologic Processes
Lung Diseases
Respiratory Tract Diseases
Respiration Disorders
Infant, Premature, Diseases
Infant, Newborn, Diseases
Trauma, Nervous System
Nervous System Diseases
Lung Injury
Wounds, Nonpenetrating
Pharmaceutical Solutions
Plasma Substitutes
Blood Substitutes