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Partner Notification for Chlamydia in Primary Care

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00112255
Recruitment Status : Completed
First Posted : June 1, 2005
Last Update Posted : January 17, 2018
Information provided by:
University of Bristol

Brief Summary:
The purpose of this study was to compare the effectiveness of partner notification by general practice nurses with referral to a specialist clinic for people with genital chlamydia diagnosed in a community setting. We hypothesised that referral to a specialist would be more effective in ensuring treatment of the sexual partners of infected people than the simpler nurse-led strategy.

Condition or disease Intervention/treatment Phase
Chlamydia Infections Behavioral: Practice nurse-led partner notification Behavioral: Referral to specialist genitourinary clinic Phase 3

Detailed Description:

Partner notification (contact tracing) is essential to the control of sexually transmitted infections. Reports of new chlamydia infections have increased by 66% in the past five years. A National Chlamydia Screening Programme in England, and increasing primary care provision of sexual health care are part of the United Kingdom Government's strategy for tackling increasing rates of sexually transmitted infections. New strategies for managing chlamydia in non-specialist settings are urgently required: genitourinary medicine clinics are failing to cope with their increasing workload; and 45% of cases detected in the chlamydia screening pilot studies were diagnosed in general practice.

Partner notification involves informing the sexual partners of someone with a sexually transmitted infection of the possibility of exposure, offering them diagnosis and treatment, and providing advice about preventing future infection. In the United Kingdom, this is usually done by specialist sexual health advisers in departments of genitourinary medicine. The effectiveness of partner notification in non-specialist settings in developed countries is not known. We conducted a randomised controlled trial to compare the effectiveness of practice nurse-led partner notification with referral to a genitourinary clinic for partner notification conducted by a specialist health adviser, and to compare the resources used by each strategy.

Comparisons: Partner notification at the time of receiving diagnosis and treatment by general practice nurses who received a one-day training course and ongoing support by telephone calls or visits from a specialist adviser in sexual health, compared with referral to a genitourinary medicine clinic for partner notification by a specialist adviser in sexual health.

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Study Type : Interventional  (Clinical Trial)
Enrollment : 214 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Partner Notification for Chlamydia in Primary Care: Randomised Controlled Trial and Economic Evaluation
Study Start Date : March 2001
Study Completion Date : December 2002

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. Percentage of index cases with at least one sexual partner treated
  2. Number of sexual partners per index case treated

Secondary Outcome Measures :
  1. Number of sexual partners per index case elicited during sexual history taking
  2. Positive chlamydia test result six weeks after treatment
  3. Adherence to advice to abstain from sexual intercourse until both partners completed treatment

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   16 Years and older   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Chlamydia trachomatis diagnosed through a population-based screening study
  • Chlamydia test result received at patient's general practice
  • Chlamydia cases diagnosed in general practice

Exclusion Criteria:

  • None

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00112255

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United Kingdom
Chlamydia Screening Studies (ClaSS) project general practices
Bristol, Avon, United Kingdom, BS8 2PR
Chlamydia Screening Studies (ClaSS) project general practices
Birmingham, West Midlands, United Kingdom, B15 2TT
Sponsors and Collaborators
University of Bristol
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Study Director: Nicola Low, MFPH Chlamydia Screening Studies (ClaSS) Project General Practices
Publications of Results:
Other Publications:
Layout table for additonal information Identifier: NCT00112255    
Other Study ID Numbers: HTA_97/32/31
First Posted: June 1, 2005    Key Record Dates
Last Update Posted: January 17, 2018
Last Verified: January 2018
Keywords provided by University of Bristol:
Chlamydia trachomatis
Chlamydia infections
Randomized controlled trials
Contact tracing
Family practice
Additional relevant MeSH terms:
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Chlamydia Infections
Chlamydiaceae Infections
Gram-Negative Bacterial Infections
Bacterial Infections
Sexually Transmitted Diseases, Bacterial
Sexually Transmitted Diseases
Genital Diseases, Male
Genital Diseases, Female