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ACCLAIM - Advanced Chronic Heart Failure CLinical Assessment of Immune Modulation Therapy

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00111969
Recruitment Status : Completed
First Posted : May 27, 2005
Last Update Posted : July 4, 2006
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Brief Summary:
The purpose of this study is to test the safety and efficacy of the Celacade™ system in reducing the risk of mortality and cardiovascular hospitalizations in patients with chronic systolic heart failure.

Condition or disease Intervention/treatment Phase
Heart Failure, Congestive Device: Celacade™ system Phase 3

Detailed Description:
Evidence continues to accumulate on the importance of inflammation in the development and progression of heart failure (HF). The Celacade™ system may reduce chronic inflammation by stimulating the immune system’s physiological anti-inflammatory response. The ACCLAIM study is an international, approximately 2,000-patient, Phase III clinical research study designed to test the safety and efficacy of the Celacade™ system in reducing the risk of mortality and cardiovascular hospitalizations in patients with chronic systolic HF.

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Study Type : Interventional  (Clinical Trial)
Enrollment : 2016 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: A Multi-Center, Randomized, Double-Blind, Parallel Group, Placebo-Controlled Study to Assess the Effects of the Celacade™ System on Mortality and Morbidity in Patients With Chronic Heart Failure
Study Start Date : June 2003
Study Completion Date : November 2005

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Failure

Primary Outcome Measures :
  1. Mortality
  2. Cardiovascular hospitalization

Secondary Outcome Measures :
  1. Clinical status
  2. Health-related patient quality
  3. Healthcare resource utilization

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Male or female aged 18 or older.
  • New York Heart Association (NYHA) Class II to IV.
  • Left ventricular ejection fraction (LVEF) ≦ 30%, measured within the past six months (by any technique), unless there was a cardiovascular event that could have modified the LVEF during that period (e.g., coronary artery bypass grafting [CABG], myocardial infarction [MI]). If the patient was started on a beta-blocker or biventricular pacing (cardiac resynchronization therapy, or CRT), the LVEF measurement must have been at least three months after starting the therapy.
  • Hospitalized for heart failure; OR, received intravenous (IV) administration of an inotropic agent (therapeutic dose for HF), human B-natriuretic peptide, or IV diuretic (minimum 40 mg of furosemide or equivalent) in a clinic, outpatient or emergency department within the past 12 months (stable for at least 2 weeks). Exceptions: patients in NYHA Class III or IV who have a LVEF of < 25%.
  • On standard therapy for congestive heart failure (CHF), which must include angiotensin converting enzyme (ACE) inhibitors or angiotensin II receptor blocker (ARB) (unless contraindicated or patient is intolerant), with or without other appropriate agents. If on a beta-blocker, patient must have been on a beta-blocker for at least three months.
  • No changes in active cardiac medications for heart failure during the two weeks prior to randomization.
  • Written informed consent

Exclusion Criteria:

  • Inability to comply with the conditions of the protocol.
  • Presence of a transplanted tissue or organ or left ventricular assist device (LVAD) (or the expectation of the same within the next 12 months).
  • Planned Automatic Implantable Cardiac Defibrillator (AICD) or CRT within the next 12 months.
  • Acute MI, or CABG, percutaneous coronary intervention (PCI), AICD, or CRT within the past three months.
  • Need for chronic intermittent inotropic therapy.
  • Malignancy: evidence of disease within the previous five years. Exceptions: basal cell carcinoma, provided that it is neither infiltrating nor sclerosing, and carcinoma in situ of the cervix.
  • Active myocarditis or early postpartum cardiomyopathy (within the first six months of delivery).
  • Systemic corticosteroids, cytostatics, immunosuppressive drug therapy (cyclophosphamide, methotrexate, cyclosporine, azathioprine, etc.), and DNA depleting or cytotoxic drugs taken within four weeks prior to study treatment.
  • Pregnancy, or patients of childbearing potential not using adequate contraceptive methods.
  • Porphyria.
  • Allergy to sodium citrate or any “caine” type of local anesthetic.
  • Previous Celacade™ treatment.
  • Patient scheduled for hospice care.
  • Clinically relevant abnormal findings in the clinical history, physical examination, electrocardiogram (ECG), or laboratory tests at the screening assessment that would interfere with the objectives of the study or that would, in the investigator’s opinion, preclude safe completion of the study. Abnormal findings could include: known HIV infection or other immunodeficiency state, chronic active viral infection (such as hepatitis B or C), acute systemic infections (defined as patients undergoing treatment with antibiotics), gastrointestinal tract bleeding, or any severe or acute concomitant illness or injury.
  • Any other medical, social, or geographical factor that would make it unlikely that the patient could comply with study procedures (e.g., alcohol abuse, lack of permanent residence, severe depression, disorientation, distant location, or a history of noncompliance).

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00111969

Sponsors and Collaborators
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Study Director: Andrea B Parker, PhD Vasogen Inc.

Additional Information:
Publications automatically indexed to this study by Identifier (NCT Number):
Layout table for additonal information Identifier: NCT00111969     History of Changes
Obsolete Identifiers: NCT00386295
Other Study ID Numbers: 0202
First Posted: May 27, 2005    Key Record Dates
Last Update Posted: July 4, 2006
Last Verified: June 2006
Keywords provided by Vasogen:
Heart failure
Immune modulation therapy
Chronic systolic heart failure
Additional relevant MeSH terms:
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Heart Failure
Heart Diseases
Cardiovascular Diseases