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The primary objective of this study is to determine which is the better approach to smoking cessation in veterans: bupropion combined with transdermal nicotine or high dose nicotine replacement therapy (NRT) using transdermal nicotine combined with nicotine inhaler.
Condition or disease
Tobacco Use Disorder
Drug: bupropion and transdermal patchDrug: transdermal patch and nicotine inhaler
This study is a two-arm open-label, randomized controlled trial of bupropion combined with transdermal nicotine versus high dose NRT (transdermal nicotine and nicotine inhaler) with all subjects receiving a behavioral counseling program for smoking cessation.
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Ages Eligible for Study:
18 Years to 65 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Readiness to set a quit date in the next two weeks,
Current smoking of at least 15 cigarettes a day
Current untreated depression or receiving treatment for depression,
History of seizures, major head injury, or other predisposition for seizures