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Study Comparing Two Types of Psychotherapy for Treating Depression and Substance Abuse

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ClinicalTrials.gov Identifier: NCT00108407
Recruitment Status : Completed
First Posted : April 15, 2005
Last Update Posted : March 6, 2009
Information provided by:
VA Office of Research and Development

Brief Summary:
The purpose of this study is to determine whether Integrated Cognitive Behavioral Therapy or Twelve Step Facilitation Therapy is most effective for treatment of dually diagnosed veterans with depressive and substance use disorders.

Condition or disease Intervention/treatment
Alcohol Abuse Cannabis Abuse Major Depressive Disorder Substance-Related Disorders Behavioral: Integrated Cognitive Behavioral Therapy Behavioral: Twelve Step Facilitation Therapy

Detailed Description:

Depression is the most frequent co-occuring mental health disorder among adults with substance use disorders, and such comorbidity is often associated with poorer treatment outcomes. Although there is an urgent need for effective treatments specific for dual-diagnosis adults, few studies have been conducted to address this need.

Comparison: This study will compare substance use and depression symptoms of individuals in two different psychotherapy groups: Integrated Cognitive Behavioral Therapy and Twelve Step Facilitation Therapy. Symptoms and substance use will be compared during the active treatment phase (24 weeks) and for one year following the end of the active treatment.

Study Type : Interventional  (Clinical Trial)
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Official Title: Integrated CBT for Substance Use and Depressive Disorders
Study Start Date : October 2004

Arm Intervention/treatment
Experimental: 1
Integrated Cognitive Behavioral Therapy
Behavioral: Integrated Cognitive Behavioral Therapy
Experimental: 2
Twelve Step Facilitation Therapy
Behavioral: Twelve Step Facilitation Therapy

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Individuals diagnosed with one or more substance use disorders (alcohol, cannabis, and or stimulant abuse/dependence) and an independent co-occurring depressive disorder (major depression or dysthymia) will be included.

Exclusion Criteria:

  • Individuals with substance induced mood disorders and individuals experiencing persistent psychotic symptoms.
  • Those with life threatening or unstable medical illness, neurological disorders, or inability to read will be excluded.
  • Individuals currently prescribed steroids, disulfiram, or long acting benzodiazepines will be excluded.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00108407

United States, California
VA San Diego Healthcare System, San Diego
San Diego, California, United States, 92161
Sponsors and Collaborators
VA Office of Research and Development
Principal Investigator: Sandra Brown, PhD VA San Diego Healthcare System, San Diego

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Brown, Sandra - Principal Investigator, Department of Veterans Affairs
ClinicalTrials.gov Identifier: NCT00108407     History of Changes
Other Study ID Numbers: MHBS-041-99Sa
First Posted: April 15, 2005    Key Record Dates
Last Update Posted: March 6, 2009
Last Verified: March 2009

Keywords provided by VA Office of Research and Development:
Alcohol Abuse/Dependence
Alcohol Use Disorders
Cannabis Abuse/Dependence
Dual diagnosis
Stimulant Abuse/Dependence
Substance Use Disorders

Additional relevant MeSH terms:
Depressive Disorder
Depressive Disorder, Major
Marijuana Abuse
Substance-Related Disorders
Pathologic Processes
Mood Disorders
Mental Disorders
Behavioral Symptoms
Chemically-Induced Disorders
Alcohol-Related Disorders