Genetic Research in Schizophrenia Using DNA Markers and Clinical Phenotypes
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|ClinicalTrials.gov Identifier: NCT00108303|
Recruitment Status : Completed
First Posted : April 15, 2005
Results First Posted : January 7, 2016
Last Update Posted : January 7, 2016
|Condition or disease||Intervention/treatment|
|Study Type :||Observational|
|Actual Enrollment :||538 participants|
|Official Title:||Genetic Research in Schizophrenia Using DNA Markers and Clinical Phenotypes in Individuals Extensively Diagnosed and Genotyped|
|Study Start Date :||January 2004|
|Actual Primary Completion Date :||December 2008|
|Actual Study Completion Date :||December 2008|
A diagnostic was performed
Diagnostic evaluation for schizophrenia. Schizophrenia includes schizophrenia and schizoaffective disorder.
- Genetic Linkage [ Time Frame: ten years ]Log of the Odds for Linkage, a standard genetic analysis metric. The number shown as a result is from a polymorphism in the promoter of the gene for the alpha7 nicotinic receptor on chromosome. Its presence in the individuals in this study, considering all three groups in one analysis, is compared to what of P50 sensory gating. P50 is a Positive wave in scalp-recorded auditory evoked potential that occurs 50 msec after the sound stimulus. P50 sensory gating is the decrement in this wave to the second of repeated sounds. The log of the odds is the common logarithm of the ratio of the odds that the gene polymorphism and P50 sensory gating are associated versus the odds that they are both distributed in the individuals at random. It is similar to the more common chi squared.
- Heritability Coefficient [ Time Frame: 5 years ]h squared which ranges from 0 to 1. This number is similar to the more standard Pearson's correlation coefficient, except that the variable, in this case P50 sensory gating, is correlated across the statuses: schizophrenia proband (has the illness), schizophrenia relative (not ill but relative of someone who is), or control (not ill and has no known ill relative, P50 is a Positive wave in scalp-recorded auditory evoked potential that occurs 50 msec after the sound stimulus. P50 sensory gating is the decrement in this wave to the second of repeated sounds.
- Log of the ODDS of Linkage [ Time Frame: 1 day ]Log of the ODDS ratio of Linkage divided by the ODDS of no linkage from a maximum likelihood analysis conducted using the statistical program LINKAGE
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00108303
|United States, Colorado|
|VA Eastern Colorado Health Care System, Denver|
|Denver, Colorado, United States, 80220|
|Principal Investigator:||Robert Freedman, MD||VA Eastern Colorado Health Care System, Denver|