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Consortium On Risk for Early-onset Parkinson's Disease (CORE PD)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified January 2012 by Columbia University.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00104585
First Posted: March 2, 2005
Last Update Posted: January 19, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
National Institute of Neurological Disorders and Stroke (NINDS)
Information provided by (Responsible Party):
Columbia University
  Purpose
The purpose of this study is to investigate genetic and environmental risk factors that increase susceptibility to the development of early-onset Parkinson's disease (developed at or before age 50).

Condition
Parkinson's Disease

Study Type: Observational
Study Design: Observational Model: Family-Based
Time Perspective: Cross-Sectional
Official Title: Genetic Epidemiology of Parkinson's Disease

Resource links provided by NLM:


Further study details as provided by Columbia University:

Biospecimen Retention:   Samples With DNA
whole blood

Estimated Enrollment: 800
Study Start Date: July 2004
Estimated Primary Completion Date: September 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts
1
People with young onset Parkinson's disease and their family members

Detailed Description:

Parkinson's disease (PD) is a common, neurodegenerative condition. Although mostly a late-onset disorder, 10 percent of people with PD are reported to develop symptoms before the age of 50. To date, six genes have been found to be associated with PD, however the majority have been found in rare PD 'families'. Some studies have also identified a number of environmental risk factors, such as pesticide use, that appear to increase the risk of PD.

In a previous study, Dr. Karen Marder and her research team found that close family members of people with both early- and late-onset PD have a three-fold increased risk of PD compared to close family members of people without PD.

The purpose of the Consortium On Risk for Early-onset Parkinson's Disease (CORE PD) study is to identify the genetic factors that contribute to the development of early-onset Parkinson's disease, and to understand how these genetic factors interact with other genes and the environment to cause PD.

Participation in the study involves a blood draw (to look for genetic factors associated with PD), questionnaires collecting information on family and medical history, and a neurological examination. In addition participants may be contacted in the future and asked to participate in a more detailed interview. At that time, study investigators will also ask participants for permission to contact family members to invite them to participate in the study.

This research study requires participants to sign a consent form, which states that the research is voluntary and confidential. In addition, since this is a research study, genetic results are not released to participants or their family members now or in the future.

Scientists hope this multi-center study will increase the current knowledge of PD and that the identification of factors that cause PD will lead to better diagnosis and treatment.

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Young onset PD patients
Criteria

Inclusion Criteria:

  • Any person with Parkinson's disease in the United States whose symptoms began at age 50 or younger and was diagnosed by a neurologist.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00104585


Contacts
Contact: Helen Mejia-Santana, M.A. 877-305-2438 research@corepdstudy.org

Locations
United States, California
The Parkinson's Institute Active, not recruiting
Sunnyvale, California, United States, 94089
United States, Connecticut
The Institute for Neurodegenerative Disorders Active, not recruiting
New Haven, Connecticut, United States, 06510
United States, Illinois
Rush University Medical Center Recruiting
Chicago, Illinois, United States, 60612
Contact: Lucia M. Blasucci    312-563-2900    Lucia_M_Blasucci@rush.edu   
Glenbrook Hospital, Evanston Active, not recruiting
Glenview, Illinois, United States, 60026
United States, Maryland
Johns Hopkins Hospital Active, not recruiting
Baltimore, Maryland, United States, 21287
United States, Minnesota
Struthers Parkinson's Center Active, not recruiting
Golden Valley, Minnesota, United States, 55427
United States, New York
Beth Israel Medical Center Active, not recruiting
New York, New York, United States, 10003
Columbia University Recruiting
New York, New York, United States, 10032
Contact: Helen Mejia-Santana    877-305-2438    research@corepdstudy.org   
United States, Pennsylvania
University of Pennsylvania Active, not recruiting
Philadelphia, Pennsylvania, United States, 19104
United States, Rhode Island
Neuro Health Active, not recruiting
Warwick, Rhode Island, United States, 02886
United States, Tennessee
University of Tennessee Health Science Center Active, not recruiting
Memphis, Tennessee, United States, 38136
United States, Wisconsin
Marshfield Clinic Active, not recruiting
Marshfield, Wisconsin, United States, 54449
Sponsors and Collaborators
Columbia University
National Institute of Neurological Disorders and Stroke (NINDS)
Investigators
Principal Investigator: Karen Marder, M.D., M.PH. Columbia University
  More Information

Responsible Party: Columbia University
ClinicalTrials.gov Identifier: NCT00104585     History of Changes
Other Study ID Numbers: AAAA5609
R01NS036630 ( U.S. NIH Grant/Contract )
First Submitted: March 1, 2005
First Posted: March 2, 2005
Last Update Posted: January 19, 2012
Last Verified: January 2012

Keywords provided by Columbia University:
Parkinson's disease
PD
gene
environment
early-onset Parkinson's disease

Additional relevant MeSH terms:
Parkinson Disease
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases