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Radiofrequency Ablation in Treating Patients Who Are Undergoing Surgery for Thyroid Cancer

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified August 2005 by National Cancer Institute (NCI).
Recruitment status was:  Active, not recruiting
National Cancer Institute (NCI)
Information provided by:
National Cancer Institute (NCI) Identifier:
First received: February 7, 2005
Last updated: September 19, 2013
Last verified: August 2005

RATIONALE: Radiofrequency ablation uses a high-frequency, electric current to kill tumor cells. Ultrasound-guided radiofrequency ablation may be effective treatment for thyroid cancer.

PURPOSE: This phase I trial is studying the side effects of radiofrequency ablation in treating patients who are undergoing surgery for thyroid cancer.

Condition Intervention Phase
Head and Neck Cancer
Procedure: conventional surgery
Procedure: radiofrequency ablation
Phase 1

Study Type: Interventional
Study Design: Primary Purpose: Treatment
Official Title: Radiofrequency Ablation for Low Risk Papillary Thyroid Cancer: A Pilot Study

Resource links provided by NLM:

Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:
  • Frequency of radiofrequency ablation-associated complications at 2 weeks

Secondary Outcome Measures:
  • Amount of tumor destruction at 2 weeks

Study Start Date: September 2004
Detailed Description:


  • Determine the frequency of complications associated with radiofrequency ablation (RFA) in patients with low-risk papillary thyroid cancer undergoing thyroidectomy.
  • Determine the utility of RFA as a treatment option for these patients.

OUTLINE: This is a pilot study.

An electrosurgical probe is placed by ultrasound guidance into the center of the thyroid tumor. Patients undergo radiofrequency ablation directly to the tumor until the target temperature is reached* for 5 minutes. Patients then undergo standard thyroidectomy.

NOTE: *Takes approximately 15-30 minutes to reach target temperature.

After completion of study treatment, patients are followed at day 1, between days 14-21, and then periodically as deemed necessary.

PROJECTED ACCRUAL: A total of 15-40 patients will be accrued for this study.


Ages Eligible for Study:   21 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No


  • Cytologically confirmed papillary thyroid cancer by fine needle aspiration

    • Low-risk disease
    • No poorly differentiated cytology
  • Intrathyroidal tumor

    • Located within the anterior two-thirds of the thyroid lobe
    • Tumor not adjacent to the trachea by neck ultrasound
  • Tumor ≤ 1.5 cm by neck ultrasound
  • Requires thyroidectomy
  • No cervical lymphadenopathy
  • No multicentric tumors by neck ultrasound
  • No evidence of lymph node metastasis



  • Over 21

Performance status

  • Not specified

Life expectancy

  • Not specified


  • Not specified


  • Not specified


  • Not specified


Biologic therapy

  • Not specified


  • Not specified

Endocrine therapy

  • Not specified


  • Not specified


  • Not specified
  Contacts and Locations
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Please refer to this study by its identifier: NCT00103155

United States, California
UCSF Comprehensive Cancer Center
San Francisco, California, United States, 94143-1674
Sponsors and Collaborators
University of California, San Francisco
National Cancer Institute (NCI)
Study Chair: Electron Kebebew, MD University of California, San Francisco
  More Information Identifier: NCT00103155     History of Changes
Other Study ID Numbers: CDR0000410790
Study First Received: February 7, 2005
Last Updated: September 19, 2013

Keywords provided by National Cancer Institute (NCI):
stage I papillary thyroid cancer

Additional relevant MeSH terms:
Head and Neck Neoplasms
Thyroid Neoplasms
Neoplasms by Site
Endocrine Gland Neoplasms
Endocrine System Diseases
Thyroid Diseases processed this record on April 25, 2017