Neuromodulation and Language Acquisition (Project Stage Ia)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00102284|
Recruitment Status : Terminated
First Posted : January 27, 2005
Last Update Posted : January 27, 2010
|Condition or disease||Intervention/treatment||Phase|
|Healthy||Drug: levodopa Drug: rivastigmine Drug: pergolid Drug: modafinil||Phase 4|
Our prior work shows that d-amphetamine and the dopamine precursor levodopa markedly improve word learning success in healthy subjects. In this randomized, placebo-controlled, double-blind clinical trial, we probe whether a mixed d1/d2 dopamine agonist (pergolid) or cholinergic neuromodulation (rivastigmine) or a general centrally arousing substance (modafinil) will yield a learning enhancement comparable to using levodopa in healthy subjects.
Our results show that the dopamine agonist pergolide impaired learning in healthy subjects compared to placebo, whereas cholinergic neuromodulation had no effect.
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||100 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||Improved Language Acquisition Through Neuromodulation, Project Stage Ia|
|Study Start Date :||March 2004|
|Study Completion Date :||April 2005|
- Boost in language learning success through neuromodulation
- Stability of language learning success
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00102284
|Dept. of Neurology, University Hospital Muenster|
|Muenster, Nordrhein-Westfalen, Germany, 48129|
|Study Director:||Caterina Breitenstein, PhD||Dept. of Neurology, University Hospital Muenster|
|Study Chair:||Stefan Knecht, MD||Dept. of Neurology, University Hospital Muenster|