Characterization of Pain Processing Mechanisms in Irritable Bowel Syndrome

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00100425
Recruitment Status : Completed
First Posted : December 31, 2004
Last Update Posted : January 21, 2009
Information provided by:
VA Office of Research and Development

Brief Summary:
The purpose of this study is to provide new information and to determine which kinds of brief, tolerable, experimental pain are affected by the drugs being studied in patients with irritable bowel syndrome, a disease that causes chronic abdominal pain. The effects of dextromethorphan, naloxone, and fentanyl on experimental pain stimuli will be tested in these studies to better understand what causes irritable bowel syndrome.

Condition or disease Intervention/treatment Phase
Irritable Bowel Syndrome Procedure: Viceral Perception Testing Not Applicable

Study Type : Interventional  (Clinical Trial)
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Double
Primary Purpose: Diagnostic
Official Title: Central Nervous System Modulation of Visceral Pain in Persian Gulf War Syndrome
Study Start Date : September 2000

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 72 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
  • Patients with irritable bowel syndrome and healthy pain-free individuals (as controls) will be studied.
  • No medical condition that would contraindicate use of dextromethorphan, fentanyl or naloxone.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00100425

United States, Florida
Malcolm Randall VA Medical Center
Gainesville, Florida, United States, 32608
Sponsors and Collaborators
VA Office of Research and Development Identifier: NCT00100425     History of Changes
Other Study ID Numbers: CADE-ARCD2
First Posted: December 31, 2004    Key Record Dates
Last Update Posted: January 21, 2009
Last Verified: December 2004

Keywords provided by VA Office of Research and Development:
Irritable Bowel Syndrome
Visceral Hypersensitivity
Visceral Pain

Additional relevant MeSH terms:
Irritable Bowel Syndrome
Visceral Pain
Pathologic Processes
Colonic Diseases, Functional
Colonic Diseases
Intestinal Diseases
Gastrointestinal Diseases
Digestive System Diseases
Nociceptive Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms