Metabolic Syndrome, Inflammation, and Risk of Cognitive Decline

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ClinicalTrials.gov Identifier: NCT00099567

Recruitment Status : Completed

First Posted : December 17, 2004

Last Update Posted : November 1, 2005

Sponsor:

Collaborators:

Paul Beeson Faculty Scholars Program

University of California, San Francisco

Information provided by:

National Institute on Aging (NIA)

Study Description

Brief Summary:

The purpose of this study is to determine if the metabolic syndrome is a risk factor for cognitive decline and if this association is modified by inflammation.

Condition or disease
Cognitive Decline

Detailed Description:

The metabolic syndrome is a clustering of several commonly occurring disorders that include abdominal obesity, high triglycerides, low HDL cholesterol, high blood pressure, and insulin resistance. This study was conducted to determine if, as hypothesized, the presence of the metabolic syndrome is associated with more cognitive decline and greater risk of developing cognitive impairment, and whether this risk is affected by the level of inflammatory markers in the blood.

This 5-year prospective observational study was conducted from 1997 to 2002 at community clinics in two locations. A total of 2632 black and white participants, aged 70 to 79 years, were recruited from the 3075 participants in the Health, Aging and Body Composition (ABC) study conducted during the same period. Participants were screened for presence of metabolic syndrome, cognitive status, inflammatory markers, and a clinic examination was administered, when the study began and at the year 3 and 5 follow-up visits.

Study Design


Study Type :	Observational
Enrollment :	2632 participants
Allocation:	Random Sample
Observational Model:	Natural History
Time Perspective:	Longitudinal
Time Perspective:	Prospective
Official Title:	Metabolic Syndrome, Inflammation, and Risk of Cognitive Decline
Study Start Date :	January 1997
Study Completion Date :	December 2002

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Metabolic Syndrome

Genetic and Rare Diseases Information Center resources: Familial Alzheimer Disease Abdominal Obesity Metabolic Syndrome

U.S. FDA Resources

Groups and Cohorts

Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:	70 Years to 79 Years (Senior)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Aged 70 to 79
White or Black
Community-dwelling in Memphis, TN or Pittsburgh, PA vicinity
Well-functioning (no difficulty in walking a quarter of a mile or going up 10 steps without resting)

Exclusion Criteria:

Any difficulty with activities of daily living
Clinical dementia
Inability to communicate with interviewer
Intention of moving out of vicinity in the next year
Active treatment for cancer in the previous 3 years
Participation in a trial involving a lifestyle intervention

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00099567

Locations


United States, Pennsylvania

Pittsburgh, Pennsylvania, United States
United States, Tennessee

Memphis, Tennessee, United States

Sponsors and Collaborators

National Institute on Aging (NIA)

Paul Beeson Faculty Scholars Program

University of California, San Francisco

Investigators


Principal Investigator:	Kristine Yaffe, MD	University of California, San Francisco

More Information

Publications of Results:

Yaffe K, Kanaya A, Lindquist K, Simonsick EM, Harris T, Shorr RI, Tylavsky FA, Newman AB. The metabolic syndrome, inflammation, and risk of cognitive decline. JAMA. 2004 Nov 10;292(18):2237-42.

Other Publications:

Yaffe K, Lindquist K, Penninx BW, Simonsick EM, Pahor M, Kritchevsky S, Launer L, Kuller L, Rubin S, Harris T. Inflammatory markers and cognition in well-functioning African-American and white elders. Neurology. 2003 Jul 8;61(1):76-80.

Kalmijn S, Foley D, White L, Burchfiel CM, Curb JD, Petrovitch H, Ross GW, Havlik RJ, Launer LJ. Metabolic cardiovascular syndrome and risk of dementia in Japanese-American elderly men. The Honolulu-Asia aging study. Arterioscler Thromb Vasc Biol. 2000 Oct;20(10):2255-60.


ClinicalTrials.gov Identifier:	NCT00099567 History of Changes
Other Study ID Numbers:	IA0066 1N01AG062106 1R01AG021918 ( U.S. NIH Grant/Contract )
First Posted:	December 17, 2004 Key Record Dates
Last Update Posted:	November 1, 2005
Last Verified:	December 2004

Keywords provided by National Institute on Aging (NIA):


Metabolic Syndrome Alzheimer's Disease Cognitive Impairment Inflammation

Additional relevant MeSH terms:


Inflammation Metabolic Syndrome X Cognitive Dysfunction Pathologic Processes Insulin Resistance Hyperinsulinism	Glucose Metabolism Disorders Metabolic Diseases Cognition Disorders Neurocognitive Disorders Mental Disorders

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