Metabolic Syndrome, Inflammation, and Risk of Cognitive Decline
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ClinicalTrials.gov Identifier: NCT00099567 |
Recruitment Status
:
Completed
First Posted
: December 17, 2004
Last Update Posted
: November 1, 2005
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Condition or disease |
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Cognitive Decline |
The metabolic syndrome is a clustering of several commonly occurring disorders that include abdominal obesity, high triglycerides, low HDL cholesterol, high blood pressure, and insulin resistance. This study was conducted to determine if, as hypothesized, the presence of the metabolic syndrome is associated with more cognitive decline and greater risk of developing cognitive impairment, and whether this risk is affected by the level of inflammatory markers in the blood.
This 5-year prospective observational study was conducted from 1997 to 2002 at community clinics in two locations. A total of 2632 black and white participants, aged 70 to 79 years, were recruited from the 3075 participants in the Health, Aging and Body Composition (ABC) study conducted during the same period. Participants were screened for presence of metabolic syndrome, cognitive status, inflammatory markers, and a clinic examination was administered, when the study began and at the year 3 and 5 follow-up visits.
Study Type : | Observational |
Enrollment : | 2632 participants |
Allocation: | Random Sample |
Observational Model: | Natural History |
Time Perspective: | Longitudinal |
Time Perspective: | Prospective |
Official Title: | Metabolic Syndrome, Inflammation, and Risk of Cognitive Decline |
Study Start Date : | January 1997 |
Study Completion Date : | December 2002 |


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Ages Eligible for Study: | 70 Years to 79 Years (Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Aged 70 to 79
- White or Black
- Community-dwelling in Memphis, TN or Pittsburgh, PA vicinity
- Well-functioning (no difficulty in walking a quarter of a mile or going up 10 steps without resting)
Exclusion Criteria:
- Any difficulty with activities of daily living
- Clinical dementia
- Inability to communicate with interviewer
- Intention of moving out of vicinity in the next year
- Active treatment for cancer in the previous 3 years
- Participation in a trial involving a lifestyle intervention

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00099567
United States, Pennsylvania | |
Pittsburgh, Pennsylvania, United States | |
United States, Tennessee | |
Memphis, Tennessee, United States |
Principal Investigator: | Kristine Yaffe, MD | University of California, San Francisco |
Publications of Results:
Other Publications:
ClinicalTrials.gov Identifier: | NCT00099567 History of Changes |
Other Study ID Numbers: |
IA0066 1N01AG062106 1R01AG021918 ( U.S. NIH Grant/Contract ) |
First Posted: | December 17, 2004 Key Record Dates |
Last Update Posted: | November 1, 2005 |
Last Verified: | December 2004 |
Keywords provided by National Institute on Aging (NIA):
Metabolic Syndrome Alzheimer's Disease Cognitive Impairment Inflammation |
Additional relevant MeSH terms:
Inflammation Metabolic Syndrome X Cognitive Dysfunction Pathologic Processes Insulin Resistance Hyperinsulinism |
Glucose Metabolism Disorders Metabolic Diseases Cognition Disorders Neurocognitive Disorders Mental Disorders |