CALERIE (Tufts) - Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy
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ClinicalTrials.gov Identifier: NCT00099099 |
Recruitment Status :
Completed
First Posted : December 9, 2004
Last Update Posted : December 11, 2009
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Aging | Behavioral: Caloric Restriction (CR) | Phase 1 |
Study Type : | Interventional (Clinical Trial) |
Enrollment : | 44 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Single |
Primary Purpose: | Prevention |
Official Title: | Dietary Energy Restriction and Metabolic Aging in Humans |
Study Start Date : | March 2002 |
Actual Primary Completion Date : | December 2004 |
Actual Study Completion Date : | December 2004 |


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Ages Eligible for Study: | 25 Years to 50 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria
- Healthy men and women
- Body mass index (BMI) = 25-30
- Slightly overweight, < 275 lbs
- Women 25-45, pre-menopause
- Men 25-50
- Not traveling often or planning to move
Exclusions:
- Cardiovascular disease or blood pressure greater than 160/90
- Diabetes
- Major psychiatric disorders
- Eating disorders
- Post obese; previous BMI > 32
- Weight change of more than ten pounds in the past 90 days
- Over 275 pounds
- Smoking
- Regular exercise, more than twice per week
- Current prescription drug use, except oral contraceptives
- Alcoholism or substance abuse
- Pregnant or lactating (breast feeding), planning to become pregnant, or not regularly using contraception
- Abnormal electrocardiogram (EKG)
- Local resident for less than one year
- Occupations requiring full alertness and motor skills, with no allowance for a chance of postural dizziness (airline pilots, etc.)
- Injuries by any metallic object that is still present in the body
- Braces, non-removable dentures, or non-removable bridgework

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00099099
United States, Massachusetts | |
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University | |
Boston, Massachusetts, United States, 02111-1524 |
Principal Investigator: | Susan B. Roberts, PhD | Jean Mayer USDA HNRCA at Tufts University |
ClinicalTrials.gov Identifier: | NCT00099099 |
Other Study ID Numbers: |
AG0006 3U01AG020480 ( U.S. NIH Grant/Contract ) |
First Posted: | December 9, 2004 Key Record Dates |
Last Update Posted: | December 11, 2009 |
Last Verified: | February 2006 |
Longevity Calorie restriction Physical activity Weight loss |