A Study to Evaluate Bevacizumab and Chemotherapy or Tarceva in Treating Recurrent or Refractory NSCLC (Non-Small Cell Lung Cancer)
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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT00095225 |
Recruitment Status :
Completed
First Posted : November 2, 2004
Last Update Posted : January 29, 2008
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Non-Small-Cell Lung Carcinoma Neoplasm Recurrence, Local | Drug: Avastin (bevacizumab) Drug: Tarceva (erlotinib HCl) | Phase 2 |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 122 participants |
Primary Purpose: | Treatment |
Official Title: | A Phase II, Multicenter, Randomized Clinical Trial to Evaluate the Efficacy and Safety of Bevacizumab in Combination With Chemotherapy (Docetaxel or Pemetrexed) or Tarceva (Erlotinib) Compared With Chemotherapy (Docetaxel or Pemetrexed) Alone for Treatment of Recurrent or Refractory Non-Small Cell Lung Cancer |
Study Start Date : | July 2004 |
Actual Study Completion Date : | November 2006 |

- To evaluate the safety and preliminary efficacy of combining bevacizumab with chemotherapy or Tarceva relative to chemotherapy alone on patients with previously treated advanced non-small cell lung cancer.

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Signed written informed consent
- Histologically or cytologically proven Stage IIIb with pleural effusion, or Stage IV, recurrent non-squamous NSCLC that is recurrent and unresectable
- Progression after one line of platinum-based chemotherapy (patients who have received prior docetaxel treatment are eligible to participate if there are no contraindications for pemetrexed treatment)
- Progression after previous adjuvant chemotherapy, if therapy was completed >= 6 months prior to randomization and the patient has received one line of therapy for recurrent disease
- (Optional) Availability of archival diagnostic tissue (paraffin tissue block or 2-10 unstained slides representative of the patient's primary cancer)
- ECOG performance status of 0, 1, or 2
- Life expectancy >= 3 months
- Measurable disease in accordance with RECIST
- Age >= 18 years
- Use of an acceptable means of contraception (potentially fertile men and women) or documentation of infertility
Exclusion Criteria:
- More than 30 days of prior treatment with an investigational or marketed agent that acts by EGFR inhibition (those with 30 or fewer days on an EGFR inhibitor without disease progression are eligible for enrollment)
- Treatment with an investigational or marketed agent that acts by anti-angiogenic mechanisms
- Previous treatment with more than one platinum-based chemotherapy
- Chemotherapy or radiotherapy within 28 days prior to randomization
- History of hemoptysis (> 1 teaspoon) or presence of a cavitary lesion
- Clinical history of Grade > 2 hematemesis within 6 months or Grade 1 hematemesis within 28 days prior to randomization
- History of serious systemic disease, including myocardial infarction within the last 6 months, uncontrolled hypertension (blood pressure > 150/100 mmHg on medication), unstable angina, New York Heart Association (NYHA) Grade II or greater congestive heart failure, unstable symptomatic arrhythmia requiring medication (patients with chronic atrial arrhythmia, i.e., atrial fibrillation or paroxysmal supraventricular tachycardia are eligible), or Grade II or greater peripheral vascular disease
- History or clinical evidence of CNS or brain metastases or CNS bleeding
- History or clinical evidence of hemorrhagic or thrombotic stroke within the 6 months prior to randomization
- Centrally located lesions and lesions that abut major blood vessels
- Ongoing treatment with full-dose warfarin (or its equivalent) or heparin (or its equivalent; e.g., Lovenox(R))
- In-patient surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to randomization
- Minor surgical procedure, fine needle aspirations, or core biopsy within 7 days prior to randomization
- Anticipation of need for a major surgical procedure during the course of the study
- Serious, non-healing wound, ulcer, or bone fracture
- Inability to take oral medication or requirement for IV alimentation or total parenteral nutrition with lipids, or prior surgical procedures affecting absorption
- Any of the following abnormal hematologic values (within 1 week prior to randomization): ANC <= 1,500 cells/uL; platelet count <= 100,000 cells/uL; Hemoglobin <= 9.0 g/dL; International normalized ratio (INR) > 1.5 x upper limit of normal (ULN)
- For patients who will receive docetaxel, any of the following abnormal liver function tests (within 1 week prior to randomization): Serum bilirubin greater than ULN; Albumin <= 2.5 g/dL; Serum ALT >= 1.5 x ULN; Serum AST >= 1.5 x ULN; Alkaline phosphatase >= 2.5 x ULN
- Other baseline laboratory values: Serum creatinine > 2.0 x ULN; Uncontrolled hypercalcemia ( > 11.5 mg/dL); Urinary protein/creatinine ratio >= 1 (spot urine) or clinically significant impairment of renal function; Estimated creatinine clearance < 45 mL/min (for patients who will receive pemetrexed)
- Any active systemic bacterial, fungal, or viral infection, including known hepatitis C and HIV
- Pregnant or breast-feeding
- Presence of another cancer within 5 years prior to randomization, except for adequately treated carcinoma in situ of the cervix or non-melanomatous skin cancer
- Evidence of confusion or disorientation, or history of major psychiatric illness that may impair the patient's understanding of the Informed Consent Form

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00095225

Study Director: | Vince O'Neill, M.D. | Genentech, Inc. |
ClinicalTrials.gov Identifier: | NCT00095225 |
Obsolete Identifiers: | NCT00098410 |
Other Study ID Numbers: |
OSI2950g |
First Posted: | November 2, 2004 Key Record Dates |
Last Update Posted: | January 29, 2008 |
Last Verified: | January 2008 |
Recurrent or refractory non-small cell lung cancer |
Lung Neoplasms Carcinoma, Non-Small-Cell Lung Neoplasm Recurrence, Local Recurrence Respiratory Tract Neoplasms Thoracic Neoplasms Neoplasms by Site Neoplasms Lung Diseases Respiratory Tract Diseases Carcinoma, Bronchogenic Bronchial Neoplasms Disease Attributes Pathologic Processes |
Neoplastic Processes Bevacizumab Erlotinib Hydrochloride Antineoplastic Agents, Immunological Antineoplastic Agents Angiogenesis Inhibitors Angiogenesis Modulating Agents Growth Substances Physiological Effects of Drugs Growth Inhibitors Protein Kinase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action |