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Mechanism of Action and Efficacy of Muraglitazar in Type 2 Diabetes

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00094991
Recruitment Status : Completed
First Posted : November 1, 2004
Last Update Posted : September 14, 2010
Merck Sharp & Dohme Corp.
Information provided by:
Bristol-Myers Squibb

Brief Summary:
The purpose of this study is to learn more about how muraglitazar lowers blood sugar in people with type 2 diabetes. The safety of this treatment will also be studied.

Condition or disease Intervention/treatment Phase
Diabetes Mellitus, Type 2 Drug: Muraglitazar Phase 3

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Study Type : Interventional  (Clinical Trial)
Enrollment : 42 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
Official Title: Mechanism of Action and Efficacy of Muraglitazar (BMS298585) in the Treatment of Type 2 Diabetic Patients
Study Start Date : May 2004
Actual Primary Completion Date : May 2006
Actual Study Completion Date : May 2006

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. The change from baseline in insulin medicated glucose disposal after 16 weeks of treatment with Muraglitazar

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Type 2 diabetes;
  • Serum triglyceride concentration < or = 600 mg/dL;
  • Body mass index < or = 37 kg/m2

Exclusion Criteria:

  • Type 1 diabetes;
  • History of myocardial infarction (MI), coronary angioplasty, bypass graft(s), valvular disease, unstable angina pectoris, transient ischemic attack (TIA), or cerebrovascular accident (CVA) within 6 months;
  • Congestive heart failure (NYHA Class III and IV);
  • Uncontrolled hypertension;
  • Women of Child Bearing Potential
  • History of renal disease, peripheral vascular disease (PVD), pulmonary disease, gastrointestinal disease, active liver disease, or endocrine disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00094991

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United States, Texas
Local Institution
San Antonio, Texas, United States, 78229-3900
Local Institution
Pisa, Italy
Sponsors and Collaborators
Bristol-Myers Squibb
Merck Sharp & Dohme Corp.
Layout table for additonal information Identifier: NCT00094991    
Other Study ID Numbers: CV168-026
First Posted: November 1, 2004    Key Record Dates
Last Update Posted: September 14, 2010
Last Verified: September 2007
Keywords provided by Bristol-Myers Squibb:
Type 2 diabetes
Additional relevant MeSH terms:
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Diabetes Mellitus, Type 2
Diabetes Mellitus
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases