An Investigational Drug for the Prevention of Chemotherapy-Induced Nausea and Vomiting (MK-0869-071)
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This protocol will study an investigational drug treatment plan against standard therapy in the prevention of chemotherapy-induced nausea and vomiting in patients diagnosed with breast cancer who are to be treated with up to 4 cycles of non-cisplatin moderately emetogenic chemotherapy.
Condition or disease
Drug: MK0869, aprepitant / Duration of Treatment: 3 daysDrug: Comparator: ondansetron / Duration of Treatment: 3 days
A Randomized, Double-Blind, Parallel-Group Study Conducted Under In-House Blinding Conditions to Determine the Efficacy and Tolerability of Aprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting Associated With Moderately Emetogenic Chemotherapy
Actual Study Start Date
October 10, 2002
Actual Primary Completion Date
December 1, 2003
Actual Study Completion Date
February 11, 2004
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patient with a diagnosis of breast cancer requiring treatment with non-cisplatin moderately emetogenic chemotherapy.
Patient has a central nervous system malignancy.
Patient will receive radiation to the abdomen or pelvis.
Signs and Symptoms, Digestive
Signs and Symptoms
Neoplasms by Site
Peripheral Nervous System Agents
Physiological Effects of Drugs
Molecular Mechanisms of Pharmacological Action
Central Nervous System Depressants
Neurokinin-1 Receptor Antagonists