Hormonal Contraception and Risk of Chlamydia and Gonorrhea
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|ClinicalTrials.gov Identifier: NCT00091728|
Recruitment Status : Terminated
First Posted : September 20, 2004
Last Update Posted : November 7, 2005
There are biological reasons to suspect that hormones may affect the risk of a woman becoming infected with a sexually transmitted disease. The evidence on this issue to date is mixed and previous studies have methodologic flaws making it difficult to draw conclusions about the results.
This study compares the risk of developing either Chlamydial or Gonorrheal infection among three groups of women: those using combined oral contraceptives (birth control pills); those using the injectable hormone (brand name Depo Provera); and those women using non-hormonal contraceptive methods.
|Condition or disease||Intervention/treatment||Phase|
|Chlamydia Infection Neisseriaceae Infection||Drug: Depo Medroxyprogesterone acetate Drug: Combined oral contraceptives||Phase 4|
The study was designed to examine the relationship between hormonal contraceptive use and possible increased risk of Chlamydial and Gonococcal sexually transmitted infections, and to determine if any increased risk appeared to be mediated by the extent of cervical ectopy.
Eight hundred and nineteen women, ages 15 to 45 years, were recruited from an inner city clinic and from a nearby suburban clinic. The women were classified into three groups based on type of contraceptive used. One group used oral contraceptives; the second used injectable depo-medroxyprogesterone acetate (DMPA); and the third group used non-hormonal contraceptive methods. Women from each group were followed at 3, 6, and 12 months after enrollment to determine if a new infection with Chlamydia or Gonorrhea had occurred and to evaluate the extent of cervical ectopy present.
|Study Type :||Observational|
|Estimated Enrollment :||1200 participants|
|Observational Model:||Defined Population|
|Observational Model:||Natural History|
|Official Title:||Hormonal Contraception, Cervical Ectopy, and STDs|
|Study Start Date :||September 1997|
|Estimated Study Completion Date :||August 2001|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00091728
|Principal Investigator:||Charles Morrison, Ph.D.||Family Health International, RTP, N.C.|
|Principal Investigator:||Paul Blumenthal, M.D.||Maryland Planned Parenthood|