Genetic Risk Factors for Severe Asthma
The purpose of this study is to determine whether a specific genetic factor influences the severity of asthma symptoms.
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Genetic Risk Factors for Severe Asthma|
- Examination of the relationship between the IL-16 promoter genotype and the presence of the asthma phenotype [ Time Frame: Throughout study ] [ Designated as safety issue: No ]
- Examination of the relationship between the IL-16 promoter genotype and asthma severity [ Time Frame: Throughout study ] [ Designated as safety issue: No ]
- Examination of the serum IL-16 concentration and the serum IL-16:IL-9, IL-16:IL-13, and IL-16: TNF-alpha ratios as possible intermediate phenotypes lining the IL-16 promoter genotype to asthma severity [ Time Frame: Throughout study ] [ Designated as safety issue: No ]
- Storage of DNA from all 600 participants for future study into the determinants of asthma severity [ Time Frame: Throughout study ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
40 mL blood
|Study Start Date:||September 2004|
|Study Completion Date:||January 2005|
|Primary Completion Date:||January 2005 (Final data collection date for primary outcome measure)|
People who have asthma
People who do not have asthma
Asthma is one of the most common chronic diseases in the United States. It is well known that asthma susceptibility is inherited; however, it is unknown if asthma severity is heritable. Studies suggest that levels of interleukin-16 (IL-16) may influence asthma severity. This study will examine the role of differences in the control region of the IL-16 gene in a racially diverse group of asthmatics and nonasthmatics and will determine if the IL-16 gene control region is related to asthma severity.
Participants in this study will undergo lung function and blood tests; they will also complete a questionnaire about their respiratory health. Asthmatic participants will complete a severity-of-asthma questionnaire.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00090740
|United States, Massachusetts|
|Boston University School of Medicine|
|Boston, Massachusetts, United States, 02118|
|Principal Investigator:||George O'Connor, MD|