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Juvenile Rheumatoid Arthritis Research Registry

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ClinicalTrials.gov Identifier: NCT00090571
Recruitment Status : Unknown
Verified June 2009 by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).
Recruitment status was:  Recruiting
First Posted : August 30, 2004
Last Update Posted : June 9, 2009
Sponsor:
Information provided by:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Brief Summary:
Juvenile rheumatoid arthritis (JRA) is the most common chronic inflammatory disease in children, and may be related to genetics. Having two siblings who both have JRA in one family is rare. The purpose of this registry is to collect patient information and blood samples from qualifying JRA siblings and their families. The goal of the registry is to further understanding of JRA as related to genetics.

Condition or disease
Juvenile Rheumatoid Arthritis

Detailed Description:

JRA is the most common chronic inflammatory pediatric rheumatic disease. JRA may be related to a complex genetic trait. It is rare to have two or more affected siblings, or sibpairs, within one family. The JRA ASP (Affected Sibpair) Registry is a nationwide effort and will collect information and blood samples from JRA sibpairs and their families. Unaffected family members (e.g., mother, father, and unaffected children) are also invited to participate.

Patients and their families may enroll in the registry in one of two ways: patients may contact the registry directly, or they may be referred to the registry through their physician. Once the family has qualified to join the registry, the family will be asked to complete a questionnaire on the medical history of their JRA-affected members. Physicians of the JRA-affected members will be asked to complete questionnaires about their patients' conditions. Family members will also be invited to provide a one-time blood sample. Information collected through the registry will help researchers identify genes involved in JRA susceptibility.


Study Type : Observational
Estimated Enrollment : 200 participants
Observational Model: Family-Based
Time Perspective: Prospective
Official Title: Research Registry for Juvenile Arthritis
Study Start Date : October 1994
Estimated Primary Completion Date : September 2009


Group/Cohort
Sib Pairs
Two or more biological siblings affected with JIA.



Biospecimen Retention:   Samples With DNA
whole blood, serum, Pax gene


Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
siblings affected with JIA
Criteria

Inclusion Criteria for Patients and Their Families:

  • At least two members of a family diagnosed with juvenile rheumatoid arthritis (JRA)
  • Informed consent from the family indicating willingness to participate in the registry

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00090571


Contacts
Contact: Sandy Kramer, CRC 513-636-7692 sandy.kramer@cchmc.org

Locations
United States, Ohio
Cincinnati Children's Hospital Medical Center Recruiting
Cincinnati, Ohio, United States, 45229-3039
Principal Investigator: David N. Glass, MD         
Sponsors and Collaborators
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Investigators
Principal Investigator: David N. Glass, MD Children's Hospital Medical Center, Cincinnati

Publications:

Responsible Party: David Glass, MD, Cincinnati Children's Hospital Medical Center
ClinicalTrials.gov Identifier: NCT00090571     History of Changes
Other Study ID Numbers: NIAMS-102
N01-AR-42218
NIAMS-102;N01-04-03
First Posted: August 30, 2004    Key Record Dates
Last Update Posted: June 9, 2009
Last Verified: June 2009

Keywords provided by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS):
JRA ASPs
Genomics

Additional relevant MeSH terms:
Arthritis
Arthritis, Rheumatoid
Arthritis, Juvenile
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases