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Juvenile Rheumatoid Arthritis Research Registry

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2009 by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).
Recruitment status was:  Recruiting
Information provided by:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Identifier:
First received: August 27, 2004
Last updated: June 5, 2009
Last verified: June 2009
Juvenile rheumatoid arthritis (JRA) is the most common chronic inflammatory disease in children, and may be related to genetics. Having two siblings who both have JRA in one family is rare. The purpose of this registry is to collect patient information and blood samples from qualifying JRA siblings and their families. The goal of the registry is to further understanding of JRA as related to genetics.

Juvenile Rheumatoid Arthritis

Study Type: Observational
Study Design: Observational Model: Family-Based
Time Perspective: Prospective
Official Title: Research Registry for Juvenile Arthritis

Resource links provided by NLM:

Further study details as provided by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS):

Biospecimen Retention:   Samples With DNA
whole blood, serum, Pax gene

Estimated Enrollment: 200
Study Start Date: October 1994
Estimated Primary Completion Date: September 2009 (Final data collection date for primary outcome measure)
Sib Pairs
Two or more biological siblings affected with JIA.

Detailed Description:

JRA is the most common chronic inflammatory pediatric rheumatic disease. JRA may be related to a complex genetic trait. It is rare to have two or more affected siblings, or sibpairs, within one family. The JRA ASP (Affected Sibpair) Registry is a nationwide effort and will collect information and blood samples from JRA sibpairs and their families. Unaffected family members (e.g., mother, father, and unaffected children) are also invited to participate.

Patients and their families may enroll in the registry in one of two ways: patients may contact the registry directly, or they may be referred to the registry through their physician. Once the family has qualified to join the registry, the family will be asked to complete a questionnaire on the medical history of their JRA-affected members. Physicians of the JRA-affected members will be asked to complete questionnaires about their patients' conditions. Family members will also be invited to provide a one-time blood sample. Information collected through the registry will help researchers identify genes involved in JRA susceptibility.


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
siblings affected with JIA

Inclusion Criteria for Patients and Their Families:

  • At least two members of a family diagnosed with juvenile rheumatoid arthritis (JRA)
  • Informed consent from the family indicating willingness to participate in the registry
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00090571

United States, Ohio
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229-3039
Sponsors and Collaborators
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Principal Investigator: David N. Glass, MD Children's Hospital Medical Center, Cincinnati
  More Information


Responsible Party: David Glass, MD, Cincinnati Children's Hospital Medical Center Identifier: NCT00090571     History of Changes
Other Study ID Numbers: NIAMS-102  N01-AR-42218  NIAMS-102;N01-04-03 
Study First Received: August 27, 2004
Last Updated: June 5, 2009

Keywords provided by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS):

Additional relevant MeSH terms:
Arthritis, Rheumatoid
Arthritis, Juvenile
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases processed this record on February 20, 2017