Study of Terlipressin Versus Placebo to Treat Hepatorenal Syndrome Type 1
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Chronic, or acute liver disease
Rapidly progressive reduction in renal function, e.g. doubling of serum creatinine to >2.5 mg/dL in less than two weeks.
No sustained improvement in renal function after diuretic withdrawal and plasma volume expansion
Proteinuria <500 mg per day
No evidence of granular casts in urinalysis or ultrasonographic evidence of obstructive uropathy or parenchymal renal disease
Uncontrolled bacterial infection
Current significant fluid losses
Current or recent treatment with nephrotoxic drugs (e.g. NSAIDs or aminoglycosides within 4 weeks)
Acute liver disease due to factors known to be also directly nephrotoxic (e.g. acetaminophen overdose)
Severe cardiovascular disease
Evidence of intrinsic or parenchymal renal disease (e.g. acute tubular necrosis)
Participation in other clinical studies within 30 days