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Trial record 5 of 49 for:    Completed Studies | cranberry

Identification of the Cranberry Juice Compounds That Prevent Urinary Tract Infections

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00087828
Recruitment Status : Completed
First Posted : July 16, 2004
Last Update Posted : August 18, 2006
Information provided by:
National Center for Complementary and Integrative Health (NCCIH)

Brief Summary:
The purpose of this study is to identify the substances in cranberry juice that make it effective in reducing urinary tract infections (UTIs) in women.

Condition or disease Intervention/treatment Phase
Urinary Tract Infections Drug: Cranberry juice cocktail Not Applicable

Detailed Description:

Urinary tract infections (UTIs) are a significant health issue, with one fourth of all women experiencing symptoms during their lifetimes. Cranberry juice has been shown to reduce the incidence of UTIs by preventing bacteria from adhering to the bladder. However, the compounds that direct this activity have not been identified. This study will identify and examine UTI-reducing compounds in cranberry juice.

Participants in this study will drink a specified amount of water following an overnight fast. Their urine will be collected 1 to 3 hours after the water is consumed. Several days later, the women will be provided with cranberry juice to replace the water in the regimen. Urine samples will be analyzed for compounds that have antibacterial or antiadhesion activity against the bacteria that cause UTIs.

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Study Type : Interventional  (Clinical Trial)
Enrollment : 5 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Cranberry Juice Metabolites in Urine
Study Start Date : November 2000
Study Completion Date : June 2005

Resource links provided by the National Library of Medicine

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years to 64 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Good overall health

Exclusion Criteria:

  • History of urinary tract infections
  • Use of cranberry products or antibiotics within 1 week of study start
  • Current use of any other medication
  • Hypertension
  • Diabetes
  • Pregnancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00087828

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United States, Illinois
Dept Medicinal Chemistry & Pharmacognosy, COP, UIC
Chicago, Illinois, United States, 60612
Sponsors and Collaborators
National Center for Complementary and Integrative Health (NCCIH)
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Principal Investigator: Susan Turner, MD UIC
Layout table for additonal information Identifier: NCT00087828    
Other Study ID Numbers: F31 AT000623-1
First Posted: July 16, 2004    Key Record Dates
Last Update Posted: August 18, 2006
Last Verified: August 2006
Keywords provided by National Center for Complementary and Integrative Health (NCCIH):
Vaccinium macrocarpon
Additional relevant MeSH terms:
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Urinary Tract Infections
Urologic Diseases