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Interaction Between Cocaine and Quetiapine - 1

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ClinicalTrials.gov Identifier: NCT00087750
Recruitment Status : Unknown
Verified March 2005 by National Institute on Drug Abuse (NIDA).
Recruitment status was:  Active, not recruiting
First Posted : July 16, 2004
Last Update Posted : January 11, 2017
Sponsor:
Information provided by:
National Institute on Drug Abuse (NIDA)

Brief Summary:
The purpose of this study is to assess the safety of intravenous (IV) cocaine in subjects taking quetiapine at 3 dosage levels.

Condition or disease Intervention/treatment Phase
Cocaine-Related Disorders Drug: Quetiapine Phase 1

Detailed Description:
A placebo-controlled, double-blind, inpatient assessment of interaction between intravenous cocaine and quetiapine (seroquel) in cocaine-experienced subjects. To assess the safety of IV cocaine in subjects taking quetiapine at 3 dosage levels.

Study Type : Interventional  (Clinical Trial)
Enrollment : 12 participants
Allocation: Randomized
Masking: Double
Primary Purpose: Treatment
Official Title: Interaction Between IV Cocaine and Quetiapine
Study Start Date : October 2003

Resource links provided by the National Library of Medicine

U.S. FDA Resources




Primary Outcome Measures :
  1. Adverse events
  2. pharmacokinetic assessment


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

Includes but is not limited to: non-treatment seeking individuals. Must meet DSM-IV criteria for cocaine abuse or dependence. Must be able to verbalize understanding of consent and provide written informed consent and verbalize willingness to complete study procedures. Site will provide further details.

Exclusion Criteria:

Please contact site for further information


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00087750


Locations
United States, Massachusetts
Boston University Medical Center
Boston, Massachusetts, United States, 02215
Sponsors and Collaborators
National Institute on Drug Abuse (NIDA)
Investigators
Principal Investigator: Domenic Ciraulo, M.D. Boston University

ClinicalTrials.gov Identifier: NCT00087750     History of Changes
Other Study ID Numbers: NIDA-MDS-0001-1
First Posted: July 16, 2004    Key Record Dates
Last Update Posted: January 11, 2017
Last Verified: March 2005

Additional relevant MeSH terms:
Cocaine-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Cocaine
Quetiapine Fumarate
Anesthetics, Local
Anesthetics
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents
Vasoconstrictor Agents
Dopamine Uptake Inhibitors
Neurotransmitter Uptake Inhibitors
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Dopamine Agents
Neurotransmitter Agents
Antipsychotic Agents
Tranquilizing Agents
Psychotropic Drugs