Interactions Between Cranberry Juice and Antibiotics Used to Treat Urinary Tract Infections
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|ClinicalTrials.gov Identifier: NCT00084201|
Recruitment Status : Completed
First Posted : June 9, 2004
Last Update Posted : November 30, 2006
|Condition or disease||Intervention/treatment|
|Urinary Tract Infections||Drug: Cranberry juice Drug: Amoxicillin|
Although evidence of its effectiveness is limited, cranberry juice is widely used to prevent urinary tract infections (UTIs). However, recent studies have shown that cranberry juice may affect the way the body absorbs and metabolizes antibiotics used to treat UTIs. This study will determine whether concurrent cranberry juice administration lowers the urinary concentrations of two commonly used antibiotics, amoxicillin and cefaclor.
This study will involve children being treated for UTIs and adults without UTIs. All of the children will continue their prescribed amoxicillin/cefaclor treatment. After 7 to 10 days of antibiotic treatment, the children will be assigned to receive either cranberry juice for 2 days or no additional treatment. Urine samples will be collected from all child participants before and after the administration of cranberry juice to examine the excretion of the antibiotics.
Adult participants will receive two different doses of amoxicillin, with or without cranberry juice. Blood and urine samples will be collected to evaluate the effect of cranberry juice on the absorption and elimination of amoxicillin.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||18 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Official Title:||Cranberry: Interactions With Anti-Infectious Agents|
|Study Start Date :||July 2006|
|Estimated Study Completion Date :||June 2007|
- Drug Elmination
- Drug absorption
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00084201
|United States, Washington|
|University of Washington|
|Seattle, Washington, United States, 98195|
|Principal Investigator:||Gail D Anderson, PhD||University of Washington|