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Interactions Between Cranberry Juice and Antibiotics Used to Treat Urinary Tract Infections

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00084201
First Posted: June 9, 2004
Last Update Posted: November 30, 2006
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Center for Complementary and Integrative Health (NCCIH)
  Purpose
The purpose of study is to determine whether cranberry juice interacts with antibiotics used to treat urinary tract infections (UTIs).

Condition Intervention
Urinary Tract Infections Drug: Cranberry juice Drug: Amoxicillin

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Cranberry: Interactions With Anti-Infectious Agents

Resource links provided by NLM:


Further study details as provided by National Center for Complementary and Integrative Health (NCCIH):

Primary Outcome Measures:
  • Drug Elmination

Secondary Outcome Measures:
  • Drug absorption

Estimated Enrollment: 18
Study Start Date: July 2006
Estimated Study Completion Date: June 2007
Detailed Description:

Although evidence of its effectiveness is limited, cranberry juice is widely used to prevent urinary tract infections (UTIs). However, recent studies have shown that cranberry juice may affect the way the body absorbs and metabolizes antibiotics used to treat UTIs. This study will determine whether concurrent cranberry juice administration lowers the urinary concentrations of two commonly used antibiotics, amoxicillin and cefaclor.

This study will involve children being treated for UTIs and adults without UTIs. All of the children will continue their prescribed amoxicillin/cefaclor treatment. After 7 to 10 days of antibiotic treatment, the children will be assigned to receive either cranberry juice for 2 days or no additional treatment. Urine samples will be collected from all child participants before and after the administration of cranberry juice to examine the excretion of the antibiotics.

Adult participants will receive two different doses of amoxicillin, with or without cranberry juice. Blood and urine samples will be collected to evaluate the effect of cranberry juice on the absorption and elimination of amoxicillin.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   6 Years to 50 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria for Children:

  • Urinary tract infection (UTI) treated with cefaclor or amoxicillin

Inclusion Criteria for Adults:

  • No UTI

Exclusion Criteria:

  • Allergies to antibiotics
  • Use of medications other than oral contraceptives
  • Pregnancy or breast-feeding
  • Smoker
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00084201


Locations
United States, Washington
University of Washington
Seattle, Washington, United States, 98195
Sponsors and Collaborators
National Center for Complementary and Integrative Health (NCCIH)
Investigators
Principal Investigator: Gail D Anderson, PhD University of Washington
  More Information

ClinicalTrials.gov Identifier: NCT00084201     History of Changes
Other Study ID Numbers: R21AT002077-01 ( U.S. NIH Grant/Contract )
First Submitted: June 8, 2004
First Posted: June 9, 2004
Last Update Posted: November 30, 2006
Last Verified: November 2006

Keywords provided by National Center for Complementary and Integrative Health (NCCIH):
Vaccinium macrocarpon

Additional relevant MeSH terms:
Infection
Urinary Tract Infections
Urologic Diseases
Amoxicillin
Anti-Bacterial Agents
Anti-Infective Agents