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Genetics of Ankylosing Spondylitis

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ClinicalTrials.gov Identifier: NCT00081562
Recruitment Status : Completed
First Posted : April 19, 2004
Last Update Posted : February 21, 2008
Sponsor:
Information provided by:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Study Description
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Brief Summary:
Ankylosing spondylitis (AS) is a chronic inflammatory disease that affects the joints between the vertebrae of the spine and the joints between the spine and the pelvis. The purpose of this study is to collect information and blood samples from patients with AS and their relatives for use in genetic studies.

Condition or disease
Spondylitis Ankylosing Spondylitis

Detailed Description:

AS is a chronic inflammatory disease that eventually causes the affected vertebrae to fuse or grow together. The cause of AS is unknown, but genetic factors seem to play a role. Risk factors include a family history of ankylosing spondylitis and male gender.

This study will collect patient information and blood samples from affected patients (and when available, both parents of the affected patients) of 400 families with children fulfillling the modified New York criteria for AS. Diagnosis of AS will be verified by patient questionnaire, medical record review, and pelvic radiographs. Information from these patients will be used to search the human genome for disease-associated loci and/or genes. This study will also utilize contributions of investigators who have conducted recent clinical or genetic research in AS at 10 academic medical centers throughout North America (the North American Spondylitis Consortium, or NASC).

Study Design
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Study Type : Observational
Enrollment : 1600 participants
Official Title: Family Studies of the Genetics of Ankylosing Spondylitis
Study Start Date : September 1999
Actual Primary Completion Date : December 2006
Actual Study Completion Date : December 2006

Resource links provided by the National Library of Medicine


Groups and Cohorts
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Outcome Measures
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Eligibility Criteria
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Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Meet modified New York criteria for ankylosing spondylitis (AS)
  • AS as confirmed by X-rays of sacroiliac joints (between the pelvis and spine)
  • At least two siblings in family with AS
  • Parents of the participants with AS have the option of also being enrolled
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00081562


Locations
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United States, California
Cedars-Sinai Medical Center
Los Angeles, California, United States, 90048
United States, Texas
University of Texas - Health Science Center at Houston
Houston, Texas, United States, 77030
Sponsors and Collaborators
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Investigators
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Principal Investigator: John D. Reveille, MD The University of Texas Health Science Center, Houston
More Information
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Additional Information:

Publications:

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ClinicalTrials.gov Identifier: NCT00081562    
Other Study ID Numbers: NIAMS-098
5R01AR046208-05 ( U.S. NIH Grant/Contract )
NASC
First Posted: April 19, 2004    Key Record Dates
Last Update Posted: February 21, 2008
Last Verified: February 2008
Additional relevant MeSH terms:
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Spondylitis
Spondylarthritis
Spondylitis, Ankylosing
Bone Diseases, Infectious
Infections
Bone Diseases
 Musculoskeletal Diseases
Spinal Diseases
Arthritis
Joint Diseases
Spondylarthropathies
Ankylosis