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Cognition, Steroids, and Imaging in Cushings Disease

This study has been completed.
Information provided by:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Identifier:
First received: April 8, 2004
Last updated: February 12, 2010
Last verified: February 2010
This study investigates the effects of the glucocorticoid hormone cortisol on brain structure and function. Patients with Cushing's disease are studied before and after treatment. Brain imaging and neuropsychologic tests are used to study changes in the hippocampus and thinking and learning functions as well as mood during the period of elevated cortisol. At several intervals after treatment, these are reexamined to study the degree of reversibility of the abnormalities. The contribution of cortisol as well as testosterone and estrogen to dysfunction and recovery is studied. Since elevated cortisol and dysregulation of its secretory system occurs in a significant proportion of the aged and in Alzheimers Disease and Major Depressive Disorder, these studies will help advance knowledge of the role of cortisol in these conditions.

Cushing Syndrome

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Cognition, Steroids, and Imaging in Cushings Disease

Resource links provided by NLM:

Further study details as provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):

Study Completion Date: December 2002

Ages Eligible for Study:   9 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion criteria:

  • patients with suspected Cushing's syndrome with clinical findings suggestive of Cushing's syndrome and positive screening tests (urinary free cortisol and low dose overnight dexamethasone suppression test).

Exclusion criteria: none

  Contacts and Locations
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Please refer to this study by its identifier: NCT00081341

United States, Michigan
General Clinical Research Center, University of Michigan Health System
Ann Arbor, Michigan, United States, 48109
Sponsors and Collaborators
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  More Information Identifier: NCT00081341     History of Changes
Other Study ID Numbers: 51337DK (completed)
Study First Received: April 8, 2004
Last Updated: February 12, 2010

Additional relevant MeSH terms:
Cushing Syndrome
Pituitary ACTH Hypersecretion
ACTH-Secreting Pituitary Adenoma
Adrenocortical Hyperfunction
Adrenal Gland Diseases
Endocrine System Diseases
Pituitary Diseases
Hypothalamic Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Pituitary Neoplasms
Endocrine Gland Neoplasms
Neoplasms by Site processed this record on May 25, 2017