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Cognitive Behavioral Therapy for Post-Traumatic Stress Disorder in Individuals With Severe Mental Illness

This study has been completed.
National Institute of Mental Health (NIMH)
Information provided by:
Medical University of South Carolina Identifier:
First received: March 5, 2004
Last updated: August 7, 2015
Last verified: December 2007
This study will develop a cognitive behavioral therapy (CBT) program to treat symptoms of post-traumatic stress disorder (PTSD) in people with severe mental illnesses who are treated within community mental health systems.

Condition Intervention Phase
Stress Disorders, Post-Traumatic Schizophrenia Behavioral: Cognitive Behavioral Therapy (CBT) Phase 2

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: CBT for PTSD and SMI in Community Mental Health Centers

Resource links provided by NLM:

Further study details as provided by Medical University of South Carolina:

Estimated Enrollment: 60
Study Start Date: January 2004
Study Completion Date: September 2007
Primary Completion Date: March 2006 (Final data collection date for primary outcome measure)
Detailed Description:

A significant proportion of people with SMI who are treated within the public sector also suffer from PTSD. Evidence suggests that these individuals often receive inadequate mental health services because effective treatments have not been explored. This study will develop and implement a CBT treatment that is designed specifically for the SMI/PTSD population.

In the first year of the study, a treatment manual and a CBT treatment model, including education, social skills training, and exposure therapy, will be developed. In the following two years, the treatment program will be tested in individuals with SMI and PTSD. Scale ratings, self-report checklists, and daily logs of behavior will be used to assess PTSD symptoms. Scale ratings and self-report surveys will also be used to measure hostility, functional status, depression and schizophrenia symptoms, and satisfaction with the study. Assessments will be made throughout the study.


Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Diagnosis of PTSD and schizophrenia or schizoaffective disorder
  • Active involvement in case management

Exclusion Criteria:

  • Suicide risk
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00078741

United States, South Carolina
Medical University of South Carolina
Charleston, South Carolina, United States, 29401
South Carolina Department of Mental Health
Columbia, South Carolina, United States, 29202
Sponsors and Collaborators
Medical University of South Carolina
National Institute of Mental Health (NIMH)
Principal Investigator: Christopher Frueh Medical University of South Carolina
  More Information Identifier: NCT00078741     History of Changes
Other Study ID Numbers: R21MH065248 ( U.S. NIH Grant/Contract )
Study First Received: March 5, 2004
Last Updated: August 7, 2015

Keywords provided by Medical University of South Carolina:
Psychotic Disorders

Additional relevant MeSH terms:
Stress Disorders, Traumatic
Stress Disorders, Post-Traumatic
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders
Trauma and Stressor Related Disorders processed this record on August 23, 2017