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Mood and Smoking: A Comparison of Smoking Cessation Treatments

This study has been completed.
Information provided by:
VA Office of Research and Development Identifier:
First received: January 12, 2004
Last updated: June 25, 2015
Last verified: June 2015


The long term objectives of this research program are:

  1. To advance the mission of the VHA Boston Healthcare System to deliver comprehensive quality healthcare that meets the needs of patients (in this case, who have been unresponsive to standard smoking cessation treatment) through research and clinical care.
  2. To expand upon our knowledge of the feasibility and effectiveness of commonly-used treatments for nicotine dependence.
  3. To further explore variables related to mood and coping that may contribute to or prevent successful reduction and cessation of smoking behavior among veterans.

The short-term objectives of this project are:

  1. To evaluate the feasibility and effectiveness of two adjunctive treatments (a mood-focused exposure-based treatment, Mood Tolerance, with Nicotine Replacement Therapy [MTNRT] and mood-focused affect-management treatment, Mood Management, with Nicotine Replacement Therapy [MMNRT]) aimed at reduction and cessation of smoking behavior among veterans who were previously non-responders to smoking cessation treatment in the VA.
  2. To inform equivocal findings in the literature regarding the role of mood as trigger for smoking behavior.
  3. To explore selected mood, coping, and individual difference variable that may be predictive of successful abstinence from cigarettes among veterans.

Condition Intervention
Smoking Cessation Mood Tolerance Mood Management Nicotine Replacement Therapy Behavioral: Mood Tolearance Behavioral: Mood Management Drug: Nicotine Replacement therapy

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single
Official Title: CSP #725 - Mood and Smoking: A Comparison of Smoking Cessation Treatments

Resource links provided by NLM:

Further study details as provided by VA Office of Research and Development:

Estimated Enrollment: 128
Study Start Date: March 2003
Estimated Study Completion Date: March 2006
  Show Detailed Description


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Outpatient veteran smokers who have previously failed a smoking cessation treatment program with nicotine replacement therapy
  Contacts and Locations
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Please refer to this study by its identifier: NCT00075972

United States, Massachusetts
Boston VA Healthcare System
Boston, Massachusetts, United States, 02103
Sponsors and Collaborators
VA Office of Research and Development
  More Information Identifier: NCT00075972     History of Changes
Other Study ID Numbers: 725
Study First Received: January 12, 2004
Last Updated: June 25, 2015

Additional relevant MeSH terms:
Ganglionic Stimulants
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Nicotinic Agonists
Cholinergic Agonists
Cholinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action processed this record on August 21, 2017