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Mood and Smoking: A Comparison of Smoking Cessation Treatments

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ClinicalTrials.gov Identifier: NCT00075972
Recruitment Status : Completed
First Posted : January 14, 2004
Last Update Posted : June 26, 2015
Information provided by:

Study Description
Brief Summary:


The long term objectives of this research program are:

  1. To advance the mission of the VHA Boston Healthcare System to deliver comprehensive quality healthcare that meets the needs of patients (in this case, who have been unresponsive to standard smoking cessation treatment) through research and clinical care.
  2. To expand upon our knowledge of the feasibility and effectiveness of commonly-used treatments for nicotine dependence.
  3. To further explore variables related to mood and coping that may contribute to or prevent successful reduction and cessation of smoking behavior among veterans.

The short-term objectives of this project are:

  1. To evaluate the feasibility and effectiveness of two adjunctive treatments (a mood-focused exposure-based treatment, Mood Tolerance, with Nicotine Replacement Therapy [MTNRT] and mood-focused affect-management treatment, Mood Management, with Nicotine Replacement Therapy [MMNRT]) aimed at reduction and cessation of smoking behavior among veterans who were previously non-responders to smoking cessation treatment in the VA.
  2. To inform equivocal findings in the literature regarding the role of mood as trigger for smoking behavior.
  3. To explore selected mood, coping, and individual difference variable that may be predictive of successful abstinence from cigarettes among veterans.

Condition or disease Intervention/treatment
Smoking Cessation Mood Tolerance Mood Management Nicotine Replacement Therapy Behavioral: Mood Tolearance Behavioral: Mood Management Drug: Nicotine Replacement therapy

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Study Design

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 128 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single
Official Title: CSP #725 - Mood and Smoking: A Comparison of Smoking Cessation Treatments
Study Start Date : March 2003
Estimated Study Completion Date : March 2006

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arms and Interventions

Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Outpatient veteran smokers who have previously failed a smoking cessation treatment program with nicotine replacement therapy
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00075972

United States, Massachusetts
Boston VA Healthcare System
Boston, Massachusetts, United States, 02103
Sponsors and Collaborators
VA Office of Research and Development
More Information

ClinicalTrials.gov Identifier: NCT00075972     History of Changes
Other Study ID Numbers: 725
First Posted: January 14, 2004    Key Record Dates
Last Update Posted: June 26, 2015
Last Verified: June 2015

Additional relevant MeSH terms:
Ganglionic Stimulants
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Nicotinic Agonists
Cholinergic Agonists
Cholinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action