Genetic Study to Identify Gene Mutations in Participants Previously Enrolled in Clinical Trial NCI-99-C-0053 Who Have Von Hippel-Lindau Syndrome or Are at Risk for Von Hippel-Lindau Syndrome
|ClinicalTrials.gov Identifier: NCT00075348|
Recruitment Status : Completed
First Posted : January 12, 2004
Last Update Posted : March 15, 2012
RATIONALE: The identification of gene mutations in individuals who have or are at risk for von Hippel-Lindau syndrome may allow doctors to better determine the genetic processes involved in the development of cancer.
PURPOSE: This genetic study is finding gene mutations in participants with von Hippel-Lindau syndrome or who are at risk for developing von Hippel-Lindau syndrome.
|Condition or disease||Intervention/treatment|
|Kidney Cancer Von Hippel-lindau Syndrome||Genetic: mutation analysis|
- Obtain laboratory identification and confirmation of research results for gene mutations in participants previously enrolled in NCI-99-C-0053 who have von Hippel-Lindau (VHL) syndrome or who are at risk for VHL syndrome.
- Determine genotype status in these participants.
OUTLINE: Participants submit a blood or buccal sample for genetic mutation analysis. Participants may receive genetic counseling and/or the results of genetic testing, if desired.
PROJECTED ACCRUAL: A maximum of 260 participants will be accrued for this study.
|Study Type :||Observational|
|Estimated Enrollment :||260 participants|
|Official Title:||Genetic Mutation Analysis In A VHL Population|
|Study Start Date :||December 2003|
|Primary Completion Date :||December 2008|
|Study Completion Date :||December 2008|
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00075348
|United States, Maryland|
|Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office|
|Bethesda, Maryland, United States, 20892-1182|
|Study Chair:||William M. Linehan, MD||NCI - Urologic Oncology Branch|