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Medication Adherence in Older People With Psychosis

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified April 2008 by Veterans Medical Research Foundation.
Recruitment status was:  Active, not recruiting
ClinicalTrials.gov Identifier:
First Posted: October 30, 2003
Last Update Posted: May 6, 2013
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
National Institute of Mental Health (NIMH)
Information provided by:
Veterans Medical Research Foundation
This study will determine whether Medication Adherence Therapy (MAT) can improve medication adherence and lower the risk of rehospitalization in older patients with psychosis.

Condition Intervention
Psychotic Disorders Schizophrenia Behavioral: Medication Adherence Therapy Behavioral: Friendly Support Group

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Official Title: Medication Adherence in Older Psychotic People

Resource links provided by NLM:

Further study details as provided by Veterans Medical Research Foundation:

Estimated Enrollment: 240
Study Start Date: September 2002
Estimated Study Completion Date: May 2007
Detailed Description:

Psychoses are among the most common and serious psychiatric disorders. Currently, the most effective treatment for psychoses involves the use of antipsychotic or neuroleptic medications. Unfortunately, pharmacologic regimens often do not achieve their goals because of poor medication adherence. Nonadherence to antipsychotic treatment is a considerable public health problem that leads to myriad clinical and economic burdens, including psychotic relapse, increased clinic and emergency room visits, and rehospitalization.

Participants in this study are randomly assigned to receive either MAT or supportive treatment for 12 weeks. MAT is given in 15 sessions and consists of motivational interviewing, education, and social skills and behavior modification. Individual MAT sessions are held in Weeks 1 and 12; small group sessions take place in Weeks 2 through 11. Three monthly booster group sessions begin in Week 16. Participants are assessed at baseline and at 3, 6, and 12 months. Medication adherence, psychopathology, quality of life, medication side effects, health beliefs, and functioning are assessed.


Information from the National Library of Medicine

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Ages Eligible for Study:   40 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • DSM-IV criteria for schizophrenia or schizoaffective disorder
  • Outpatient status at the time of enrollment
  • Currently prescribed maintenance treatment with antipsychotic medication (typical or atypical, oral or depot)
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00071604

United States, California
Division of Geriatric Psychiatry Center (University of California, San Diego)
San Diego, California, United States, 92161
Sponsors and Collaborators
Veterans Medical Research Foundation
National Institute of Mental Health (NIMH)
Principal Investigator: Jonathan Lacro, PharmD VA San Diego Healthcare System & University of California, San Diego
  More Information

Additional Information:
ClinicalTrials.gov Identifier: NCT00071604     History of Changes
Other Study ID Numbers: R01MH062849 ( U.S. NIH Grant/Contract )
First Submitted: October 29, 2003
First Posted: October 30, 2003
Last Update Posted: May 6, 2013
Last Verified: April 2008

Additional relevant MeSH terms:
Mental Disorders
Psychotic Disorders
Schizophrenia Spectrum and Other Psychotic Disorders