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Medication Adherence in Older People With Psychosis

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ClinicalTrials.gov Identifier: NCT00071604
Recruitment Status : Unknown
Verified April 2008 by Veterans Medical Research Foundation.
Recruitment status was:  Active, not recruiting
First Posted : October 30, 2003
Last Update Posted : May 6, 2013
Sponsor:
Collaborator:
National Institute of Mental Health (NIMH)
Information provided by:
Veterans Medical Research Foundation

Brief Summary:
This study will determine whether Medication Adherence Therapy (MAT) can improve medication adherence and lower the risk of rehospitalization in older patients with psychosis.

Condition or disease Intervention/treatment Phase
Psychotic Disorders Schizophrenia Behavioral: Medication Adherence Therapy Behavioral: Friendly Support Group Not Applicable

Detailed Description:

Psychoses are among the most common and serious psychiatric disorders. Currently, the most effective treatment for psychoses involves the use of antipsychotic or neuroleptic medications. Unfortunately, pharmacologic regimens often do not achieve their goals because of poor medication adherence. Nonadherence to antipsychotic treatment is a considerable public health problem that leads to myriad clinical and economic burdens, including psychotic relapse, increased clinic and emergency room visits, and rehospitalization.

Participants in this study are randomly assigned to receive either MAT or supportive treatment for 12 weeks. MAT is given in 15 sessions and consists of motivational interviewing, education, and social skills and behavior modification. Individual MAT sessions are held in Weeks 1 and 12; small group sessions take place in Weeks 2 through 11. Three monthly booster group sessions begin in Week 16. Participants are assessed at baseline and at 3, 6, and 12 months. Medication adherence, psychopathology, quality of life, medication side effects, health beliefs, and functioning are assessed.


Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 240 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Official Title: Medication Adherence in Older Psychotic People
Study Start Date : September 2002
Study Completion Date : May 2007

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Ages Eligible for Study:   40 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • DSM-IV criteria for schizophrenia or schizoaffective disorder
  • Outpatient status at the time of enrollment
  • Currently prescribed maintenance treatment with antipsychotic medication (typical or atypical, oral or depot)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00071604


Locations
United States, California
Division of Geriatric Psychiatry Center (University of California, San Diego)
San Diego, California, United States, 92161
Sponsors and Collaborators
Veterans Medical Research Foundation
National Institute of Mental Health (NIMH)
Investigators
Principal Investigator: Jonathan Lacro, PharmD VA San Diego Healthcare System & University of California, San Diego

Additional Information:
ClinicalTrials.gov Identifier: NCT00071604     History of Changes
Other Study ID Numbers: R01MH062849 ( U.S. NIH Grant/Contract )
R01MH062849 ( U.S. NIH Grant/Contract )
DATR A4-GPS
First Posted: October 30, 2003    Key Record Dates
Last Update Posted: May 6, 2013
Last Verified: April 2008

Additional relevant MeSH terms:
Schizophrenia
Mental Disorders
Psychotic Disorders
Schizophrenia Spectrum and Other Psychotic Disorders