Middle School to High School Transition Project: Depression and Substance Abuse Prevention

This study has been completed.
Information provided by:
National Institute of Mental Health (NIMH)
ClinicalTrials.gov Identifier:
First received: October 24, 2003
Last updated: September 22, 2008
Last verified: September 2008
This study will implement a school-based program to prevent depression, academic failure, and substance use in at-risk adolescents transitioning from middle school to high school.

Condition Intervention Phase
Substance-Related Disorders
Behavioral: Coping and Support Training for Transition program
Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: Middle School to High School Transition Project

Further study details as provided by National Institute of Mental Health (NIMH):

Estimated Enrollment: 400
Study Start Date: March 2003
Estimated Study Completion Date: June 2007
Detailed Description:

The transition from middle school to high school presents important challenges for adolescents. Programs that enhance personal efficacy and social support resources may prevent at-risk students from developing behaviors that can lead to substance use, academic failure, and depression. This study will implement a skills-based program called Coping and Support Training for the Transition (CAST-T) as a preventive intervention for at-risk students.

At-risk students in eighth grade will be randomly assigned to receive either CAST-T or school as usual. The CAST-T program will initially be delivered in twelve sessions over 6 weeks in the middle school setting. The program includes booster sessions, case management, structured home-based parent education, and support and skills training throughout the transition period. Participants will be assessed from the beginning of eighth grade to the end of ninth grade. Vulnerability to academic problems and depression will be assessed with school records and self-report scale scores.


Ages Eligible for Study:   12 Years to 15 Years   (Child)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • At-risk for substance abuse, academic failure, and depression
  • Enrolled in eighth grade in Seattle Public Schools
  • English-speaking
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00071513

United States, Washington
University of Washington
Seattle, Washington, United States, 98195
Sponsors and Collaborators
National Institute of Mental Health (NIMH)
Principal Investigator: Elizabeth McCauley, PhD University of Washington
Principal Investigator: Ann Vander Stoep, PhD University of Washington
  More Information

Additional Information:
ClinicalTrials.gov Identifier: NCT00071513     History of Changes
Other Study ID Numbers: R01MH061984  DSIR 84-CTP 
Study First Received: October 24, 2003
Last Updated: September 22, 2008
Health Authority: United States: Federal Government

Keywords provided by National Institute of Mental Health (NIMH):
Substance Abuse

Additional relevant MeSH terms:
Depressive Disorder
Substance-Related Disorders
Behavioral Symptoms
Mood Disorders
Mental Disorders
Chemically-Induced Disorders

ClinicalTrials.gov processed this record on July 25, 2016